{"id":"W3170038569","doi":"10.1016/s0140-6736(21)00592-4","title":"Isatuximab, carfilzomib, and dexamethasone in relapsed multiple myeloma (IKEMA): a multicentre, open-label, randomised phase 3 trial","year":2021,"lang":"en","type":"article","venue":"The Lancet","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":380,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hotel Dieu Hospital","funders":"Sanofi Genzyme; Sanofi","keywords":"Carfilzomib; Medicine; Dexamethasone; Multiple myeloma; Internal medicine; Population; Oncology; Lenalidomide","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009220915,0.0002508837,0.00107928,0.00008397359,0.0001510565,0.0001309667,0.0003102669,0.0001111047,0.0002443585],"category_scores_gemma":[0.003029604,0.0001655613,0.00006833759,0.0003911193,0.0001461121,0.0001015053,0.0002980421,0.000443326,0.00005646901],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001124266,"about_ca_system_score_gemma":0.0002603452,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003825265,"about_ca_topic_score_gemma":0.0005376586,"domain_scores_codex":[0.9974769,0.0005652061,0.0004218092,0.0004990904,0.0003822085,0.0006547651],"domain_scores_gemma":[0.9974505,0.0012112,0.0001039497,0.0008442442,0.0001113805,0.0002787456],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9072596,0.005159969,0.01162848,0.0001537681,0.0005360754,0.002218251,0.001239236,0.000002195819,0.02032816,0.00008958502,0.003807313,0.04757731],"study_design_scores_gemma":[0.9757557,0.0007544903,0.0083507,0.000159048,0.0001364348,0.00008763478,0.0002721852,0.004996797,0.005575037,0.0001011412,0.003631604,0.0001792589],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9879231,0.001867268,0.00002179953,0.003830899,0.0001614119,0.003510627,0.00008781315,0.00004833114,0.002548677],"genre_scores_gemma":[0.9916241,0.0005879515,0.004332611,0.0007990187,0.0004637402,0.0003829018,0.0001284942,0.00003813141,0.001643083],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06849601,"threshold_uncertainty_score":0.6751392,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1055133731748032,"score_gpt":0.388914458078011,"score_spread":0.2834010849032078,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}