{"id":"W3170038569","doi":"10.1016/s0140-6736(21)00592-4","title":"Isatuximab, carfilzomib, and dexamethasone in relapsed multiple myeloma (IKEMA): a multicentre, open-label, randomised phase 3 trial","year":2021,"lang":"en","type":"article","venue":"The Lancet","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":380,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hotel Dieu Hospital","funders":"Sanofi Genzyme; Sanofi","keywords":"Carfilzomib; Medicine; Dexamethasone; Multiple myeloma; Internal medicine; Population; Oncology; Lenalidomide","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002204221,0.001980276,0.004027249,0.000365003,0.0004524103,0.001433719,0.0009846884,0.002033833,0.007155163],"category_scores_gemma":[0.001620054,0.0006205163,0.00281166,0.0005615425,0.001273899,0.001132764,0.0005993033,0.004264979,0.00117704],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001066522,"about_ca_system_score_gemma":0.001184577,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001621664,"about_ca_topic_score_gemma":0.003140687,"domain_scores_codex":[0.9992321,0.0003807716,0.00003403725,0.0001240319,0.0000532375,0.0001758899],"domain_scores_gemma":[0.9990667,0.0002913429,0.0002005444,0.00007061521,0.00004707057,0.000323754],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9840492,0.001654704,0.0003636566,0.000592781,0.0009889458,0.00002878202,0.00003272372,0.0002386802,0.000971677,0.00009190119,0.0008217315,0.01016533],"study_design_scores_gemma":[0.9747998,0.02289455,0.001045515,0.00003677545,0.0003969262,0.00002868446,0.00001777017,0.0001346403,0.00008704263,0.000113658,0.0004341521,0.00001050987],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9656377,0.02280273,0.0006890437,0.002073312,0.001385501,0.002904648,0.001593285,0.0001691124,0.002744631],"genre_scores_gemma":[0.9804147,0.007241882,0.001390798,0.002216059,0.0007683274,0.0027978,0.001529812,0.0000296163,0.003610913],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007155163,"threshold_uncertainty_score":0.02393639,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1055133731748032,"score_gpt":0.388914458078011,"score_spread":0.2834010849032078,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}