{"id":"W3170042501","doi":"10.3233/jnd-210689","title":"A Randomized, Double-Blind, Placebo-Controlled, Global Phase 3 Study of Edasalonexent in Pediatric Patients with Duchenne Muscular Dystrophy: Results of the PolarisDMD Trial","year":2021,"lang":"en","type":"article","venue":"Journal of Neuromuscular Diseases","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine; Children's Hospital of Eastern Ontario","funders":"","keywords":"Medicine; Duchenne muscular dystrophy; Placebo; Adverse effect; Statistical significance; Internal medicine; Clinical endpoint; Muscular dystrophy; Randomized controlled trial; Ambulatory; Clinical trial; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004220271,0.0002396905,0.0009534308,0.00009359579,0.00005421467,0.00001505677,0.0003427086,0.0001010444,0.000006311087],"category_scores_gemma":[0.0009674852,0.0001487775,0.0007637593,0.0003511329,0.0001309242,0.00001634259,0.000131931,0.000184212,2.393016e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001513698,"about_ca_system_score_gemma":0.0004215759,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003813922,"about_ca_topic_score_gemma":0.00003836933,"domain_scores_codex":[0.996736,0.001079594,0.00111407,0.0003192994,0.0005336181,0.0002174085],"domain_scores_gemma":[0.9976253,0.00009408033,0.001122358,0.0005155767,0.0005170873,0.0001256283],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9718068,0.009523231,0.01494548,0.00004753868,0.0006211125,0.00004756115,0.00005054482,0.001606483,0.001228695,0.000005583219,0.00004881683,0.00006819435],"study_design_scores_gemma":[0.9593861,0.003505226,0.03503247,0.00002589653,0.001269319,0.000005372543,0.0001451274,0.000010593,0.0004298997,0.00002932575,0.00002272886,0.0001379867],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962119,0.001663165,0.00002192449,0.00007385619,0.0003055168,0.001628263,0.00006857009,0.000002043407,0.00002469733],"genre_scores_gemma":[0.9995075,0.0001587876,0.00002035604,0.00003790577,0.0001834302,0.00003642927,0.00003485845,0.00001573396,0.000004994201],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02008699,"threshold_uncertainty_score":0.606697,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01090407759977987,"score_gpt":0.2718098570398603,"score_spread":0.2609057794400805,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}