{"id":"W3170042501","doi":"10.3233/jnd-210689","title":"A Randomized, Double-Blind, Placebo-Controlled, Global Phase 3 Study of Edasalonexent in Pediatric Patients with Duchenne Muscular Dystrophy: Results of the PolarisDMD Trial","year":2021,"lang":"en","type":"article","venue":"Journal of Neuromuscular Diseases","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine; Children's Hospital of Eastern Ontario","funders":"","keywords":"Medicine; Duchenne muscular dystrophy; Placebo; Adverse effect; Statistical significance; Internal medicine; Clinical endpoint; Muscular dystrophy; Randomized controlled trial; Ambulatory; Clinical trial; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00155324,0.001246088,0.002367208,0.0002553818,0.0003125529,0.0007221723,0.0006833005,0.001204337,0.004989099],"category_scores_gemma":[0.001165161,0.000413885,0.001467246,0.0002655306,0.0007454263,0.0005945001,0.0002536282,0.001916181,0.000557154],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000653011,"about_ca_system_score_gemma":0.001119641,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007386073,"about_ca_topic_score_gemma":0.002197746,"domain_scores_codex":[0.9995322,0.000244846,0.00002709913,0.00008492146,0.00004608231,0.00006490248],"domain_scores_gemma":[0.9993388,0.0001589093,0.0002109632,0.00004527508,0.00005358331,0.0001924241],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9654456,0.006298047,0.001597497,0.0009674386,0.001036151,0.00009130338,0.00007986271,0.0003720209,0.004032108,0.0001480448,0.001319592,0.01861234],"study_design_scores_gemma":[0.9463983,0.04866785,0.003312979,0.00004665762,0.0002661062,0.00006341563,0.00001972065,0.0001958052,0.0003021703,0.00006647549,0.0006517905,0.000008872998],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9854453,0.006871284,0.0005802322,0.0006290663,0.0002500533,0.002580488,0.001676715,0.0001179014,0.001848938],"genre_scores_gemma":[0.9791783,0.005328181,0.002338551,0.001654033,0.0003181502,0.005923712,0.002334628,0.00003483764,0.002889534],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004989099,"threshold_uncertainty_score":0.01669014,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01090407759977987,"score_gpt":0.2718098570398603,"score_spread":0.2609057794400805,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}