{"id":"W3170140538","doi":"10.1093/genetics/iyab095","title":"Mitochondrial perturbation reduces susceptibility to xenobiotics through altered efflux in <i>Candida albicans</i>","year":2021,"lang":"en","type":"article","venue":"Genetics","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health; Canada Research Chairs","keywords":"Geldanamycin; Biology; Efflux; Candida albicans; Hsp90; Corpus albicans; Mutant; Cell biology; Genetics; ATP-binding cassette transporter; Gene; Heat shock protein; Transporter","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000847298,0.0002389909,0.0002626324,0.0001522917,0.0001410284,0.0003652321,0.0003235179,0.0002349109,0.001173415],"category_scores_gemma":[0.0001123354,0.00008865002,0.0001930158,0.0001509377,0.0001393973,0.00011048,0.0001426544,0.0004907316,0.0002743639],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000285362,"about_ca_system_score_gemma":0.0002315473,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001926937,"about_ca_topic_score_gemma":0.002369006,"domain_scores_codex":[0.9998661,0.0000156801,0.00001863962,0.00002634098,0.00003882097,0.00003437747],"domain_scores_gemma":[0.9999213,0.000008473018,0.00002080255,0.000007609331,0.00001488179,0.00002681792],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001793124,0.00004804589,0.0001757462,0.00002707119,0.000005352456,0.00002434299,0.000007433715,0.00004353407,0.9983741,0.00003643702,0.00008574276,0.0009927413],"study_design_scores_gemma":[0.0000206044,0.0005731313,0.008510498,0.00001134167,0.00002619907,0.0001314449,0.00004539962,0.0007479773,0.98761,0.00002667077,0.002289387,0.000007283514],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962322,0.0008266693,0.0006798622,0.000143245,0.0000264733,0.00002287547,0.0008975092,0.00009886169,0.001072255],"genre_scores_gemma":[0.9951786,0.000590628,0.0009306297,0.0001089693,0.000007423686,0.00003029293,0.00116205,0.00003280329,0.001958485],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001926937,"threshold_uncertainty_score":0.003925443,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02407381779706099,"score_gpt":0.3090020295902294,"score_spread":0.2849282117931684,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}