{"id":"W3170140538","doi":"10.1093/genetics/iyab095","title":"Mitochondrial perturbation reduces susceptibility to xenobiotics through altered efflux in <i>Candida albicans</i>","year":2021,"lang":"en","type":"article","venue":"Genetics","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health; Canada Research Chairs","keywords":"Geldanamycin; Biology; Efflux; Candida albicans; Hsp90; Corpus albicans; Mutant; Cell biology; Genetics; ATP-binding cassette transporter; Gene; Heat shock protein; Transporter","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001681398,0.00020003,0.000397489,0.00004841645,0.00006894572,0.00003691262,0.0001161701,0.0001874618,0.0003678994],"category_scores_gemma":[0.0005936276,0.0001930441,0.0001222723,0.0004609549,0.0001064817,0.00005346362,0.00007862032,0.000266532,0.00006067741],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002143369,"about_ca_system_score_gemma":0.0004747476,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000472084,"about_ca_topic_score_gemma":0.001608658,"domain_scores_codex":[0.9979829,0.0001113158,0.0004760946,0.0006088861,0.0004221833,0.0003986346],"domain_scores_gemma":[0.9986617,0.00009854559,0.00005787904,0.0006870253,0.0003104465,0.0001843873],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006735429,0.0007436058,0.2323177,0.0002224691,0.00005837926,0.00007836697,0.002764851,0.0001846746,0.7479813,0.0002176954,0.009851334,0.004906122],"study_design_scores_gemma":[0.003356368,0.0008295206,0.436594,0.0002844756,0.000156178,0.00003872943,0.001942046,0.000271232,0.5180323,0.002472376,0.03542158,0.0006012541],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9920174,0.0005363567,0.001125139,0.002064392,0.0006811026,0.0005127901,0.00003216639,0.00003757646,0.002993074],"genre_scores_gemma":[0.9789727,0.0002045896,0.01645429,0.001555069,0.0006200374,0.00001064928,0.00008359877,0.00002521331,0.002073803],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.229949,"threshold_uncertainty_score":0.787211,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02407381779706099,"score_gpt":0.3090020295902294,"score_spread":0.2849282117931684,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}