{"id":"W3170144160","doi":"10.1002/jbmr.4388","title":"<i>Dmp1Cre-</i> directed knockdown of parathyroid hormone–related protein (PTHrP) in murine decidua is associated with a life-long increase in bone mass, width, and strength in male progeny","year":2020,"lang":"en","type":"article","venue":"Journal of Bone and Mineral Research","topic":"Bone health and treatments","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland","funders":"National Health and Medical Research Council; Medical Research Council; State Government of Victoria; University of Melbourne","keywords":"Endocrinology; Decidua; Internal medicine; Parathyroid hormone-related protein; Parathyroid hormone; Cortical bone; Biology; Placenta; Osteopenia; Decidual cells; In utero; Bone mineral; Medicine; Pregnancy; Fetus; Osteoporosis; Genetics; Anatomy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002586258,0.000420572,0.0003160932,0.0005195905,0.0002620234,0.0004155792,0.0004027362,0.0004627548,0.002347457],"category_scores_gemma":[0.0001422922,0.0004027326,0.0003710611,0.0001656703,0.0005084983,0.0002182776,0.000383597,0.001021995,0.0009265207],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003186873,"about_ca_system_score_gemma":0.000165673,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000483675,"about_ca_topic_score_gemma":0.000854241,"domain_scores_codex":[0.9995536,0.00004772413,0.00005071455,0.0001300266,0.0001208021,0.00009697432],"domain_scores_gemma":[0.9995081,0.00006057456,0.0001891583,0.00004343679,0.00002430952,0.0001743239],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005536751,0.00001289577,0.0001107534,0.00001284297,0.000001871301,0.000058562,0.000009587704,0.000008435473,0.9993659,0.00005443654,0.00003078852,0.0002784606],"study_design_scores_gemma":[0.00001676158,0.0001526682,0.005628614,0.000006312516,0.00001113109,0.0005068504,0.00003219652,0.0002243241,0.9916812,0.00002716136,0.001708059,0.000004741809],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.988726,0.001374993,0.005244697,0.0002306208,0.0000854314,0.00004347766,0.001659094,0.0003388452,0.002296783],"genre_scores_gemma":[0.9806363,0.0008310729,0.00436452,0.0002040738,0.00004573718,0.0001337329,0.001712928,0.0002928493,0.01177883],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002347457,"threshold_uncertainty_score":0.007853091,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03307070708817929,"score_gpt":0.3165227281815263,"score_spread":0.2834520210933471,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}