{"id":"W3170186649","doi":"10.1002/hep.32011","title":"The Serum Proteome and Ursodeoxycholic Acid Response in Primary Biliary Cholangitis","year":2021,"lang":"en","type":"article","venue":"Hepatology","topic":"Liver Diseases and Immunity","field":"Medicine","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Liver Centre; University of Toronto","funders":"Academy of Medical Sciences; Medical Research Council; National Institute for Health and Care Research; Pfizer","keywords":"Ursodeoxycholic acid; Chemokine; Medicine; Proteome; Internal medicine; Immunology; Gastroenterology; Cohort; Biology; Bioinformatics; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002829464,0.00008208511,0.0001961265,0.0000492451,0.00009587338,0.00001494778,0.00005922574,0.00008474864,0.00007267502],"category_scores_gemma":[0.000285134,0.00005930541,0.00004145431,0.0001633222,0.0001294205,0.0000506384,0.0001111734,0.0002389251,0.00002538058],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005155722,"about_ca_system_score_gemma":0.000268469,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006052402,"about_ca_topic_score_gemma":0.00003429295,"domain_scores_codex":[0.998996,0.0003572181,0.000149512,0.0001816606,0.00007921379,0.0002363589],"domain_scores_gemma":[0.9993163,0.0001666004,0.00002768514,0.0003576104,0.00004666619,0.00008508965],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002119638,0.0001480967,0.9746246,0.00007343201,0.00004018629,0.0009795605,0.0002955348,3.316845e-8,0.01396455,0.0001084899,0.0006662441,0.006979678],"study_design_scores_gemma":[0.001121664,0.0001565079,0.9830112,0.0000337069,0.00002553609,0.000763958,0.0001222745,0.00004128746,0.002023582,0.0002142108,0.01242088,0.00006517019],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9844815,0.005228037,0.000002573859,0.009035602,0.0001006894,0.0002324545,0.00001331632,0.00002375597,0.0008821296],"genre_scores_gemma":[0.9959867,0.0009086614,0.00008312776,0.002237237,0.00002876696,0.00003904718,0.00001505779,0.00001063434,0.0006907543],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01194097,"threshold_uncertainty_score":0.2418405,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01223205277238177,"score_gpt":0.2573415638316951,"score_spread":0.2451095110593133,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}