{"id":"W3170186649","doi":"10.1002/hep.32011","title":"The Serum Proteome and Ursodeoxycholic Acid Response in Primary Biliary Cholangitis","year":2021,"lang":"en","type":"article","venue":"Hepatology","topic":"Liver Diseases and Immunity","field":"Medicine","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Liver Centre; University of Toronto","funders":"Academy of Medical Sciences; Medical Research Council; National Institute for Health and Care Research; Pfizer","keywords":"Ursodeoxycholic acid; Chemokine; Medicine; Proteome; Internal medicine; Immunology; Gastroenterology; Cohort; Biology; Bioinformatics; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001021338,0.0003404477,0.000389233,0.0007755957,0.0002119306,0.0005094726,0.0001383976,0.0004517384,0.0006623552],"category_scores_gemma":[0.002448821,0.0001632778,0.0002560787,0.0006746848,0.0002776977,0.0002688027,0.0004901873,0.000281302,0.0001981464],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002916814,"about_ca_system_score_gemma":0.0001820683,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000797673,"about_ca_topic_score_gemma":0.0006341925,"domain_scores_codex":[0.999545,0.0001737963,0.00006134033,0.00008851686,0.00008545093,0.00004578223],"domain_scores_gemma":[0.9987231,0.0003377534,0.0005675709,0.00007358735,0.0001746261,0.0001233065],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001526848,0.0000438777,0.984704,0.00004725233,0.00008547385,0.00008654566,0.00007013897,0.0002152767,0.008015702,0.00001570739,0.00008714088,0.005101994],"study_design_scores_gemma":[0.00001102849,0.0002306954,0.9970418,0.000006036648,0.00002797113,0.0003607718,0.00004566826,0.0007074093,0.001414745,0.00002415117,0.0001262967,0.000003445379],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990708,0.0005226921,0.0001365766,0.00002536569,0.000003789035,0.000004822514,0.00009638115,0.000007494029,0.0001321184],"genre_scores_gemma":[0.9995418,0.00007819378,0.000176934,0.00001230578,0.000004736163,0.000004163974,0.0001338924,0.000001375726,0.00004653392],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001021338,"threshold_uncertainty_score":0.005401433,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01223205277238177,"score_gpt":0.2573415638316951,"score_spread":0.2451095110593133,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}