{"id":"W3170198976","doi":"10.1200/jco.2021.39.15_suppl.3005","title":"Initial results from a dose finding study of TNO155, a SHP2 inhibitor, in adults with advanced solid tumors.","year":2021,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"Novartis","keywords":"Medicine; Tolerability; Pharmacodynamics; Adverse effect; Pharmacokinetics; Internal medicine; Regimen; Oncology; Gastroenterology; Pharmacology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00145805,0.0001646212,0.001107418,0.00007138134,0.00002494476,0.000008925675,0.0002770214,0.0002892491,0.00001487701],"category_scores_gemma":[0.008044064,0.0001311983,0.0001768554,0.0001805889,0.000135651,0.00001631355,0.0002188286,0.0005878916,0.000001589735],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003514728,"about_ca_system_score_gemma":0.001704664,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009476574,"about_ca_topic_score_gemma":0.001347815,"domain_scores_codex":[0.9958072,0.0006318556,0.002665563,0.0003756588,0.0002907219,0.0002290364],"domain_scores_gemma":[0.9962742,0.0006899153,0.002054373,0.0003379331,0.000474232,0.0001693285],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.3544821,0.04100738,0.1276294,0.0001398968,0.001970901,0.01992991,0.002899573,0.002639255,0.1108797,0.000109726,0.004094354,0.3342179],"study_design_scores_gemma":[0.1184426,0.1077757,0.2583261,0.001351546,0.0002503222,0.000363351,0.003645898,0.00005908147,0.5021689,0.0003691905,0.006636215,0.0006110692],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970691,0.001628059,0.00004870169,0.0003335983,0.0004380127,0.0002291378,0.00006979737,0.000002496122,0.0001811192],"genre_scores_gemma":[0.9947042,0.0002686314,0.003921254,0.0002715344,0.000744537,0.000007997905,0.00004916552,0.00001785762,0.00001481281],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3912892,"threshold_uncertainty_score":0.9630077,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05399099045793521,"score_gpt":0.4246390614126213,"score_spread":0.3706480709546861,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}