{"id":"W3170205233","doi":"10.1101/2021.06.15.447407","title":"Sexual dimorphism in a neuronal mechanism of spinal hyperexcitability across rodent and human models of pathological pain","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Pain Mechanisms and Treatments","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Université Laval; Carleton University; Institut Universitaire en Santé Mentale de Québec; Ottawa Hospital","funders":"Canadian Institutes of Health Research; Pfizer Canada; Canadian Pain Society; International Association for the Study of Pain; Natural Sciences and Engineering Research Council of Canada; Pfizer","keywords":"Disinhibition; Neuroscience; NMDA receptor; Hyperalgesia; Allodynia; Biology; Medicine; Nociception; Psychology; Internal medicine; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003562073,0.0001417356,0.0002213203,0.000388743,0.00009108095,0.0002137385,0.0001368196,0.0001917684,0.00236612],"category_scores_gemma":[0.000423882,0.0001133893,0.0001499673,0.0001550224,0.000222526,0.000156974,0.0001928611,0.0003188295,0.000266372],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001049006,"about_ca_system_score_gemma":0.0000908958,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001853031,"about_ca_topic_score_gemma":0.0002827575,"domain_scores_codex":[0.9997645,0.00005919048,0.00002556183,0.00005588778,0.00006328036,0.00003167184],"domain_scores_gemma":[0.9997993,0.00003493269,0.00007771102,0.00003638278,0.00002236564,0.00002927606],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002344955,0.0003316025,0.02629261,0.0002402439,0.0001283256,0.0009330508,0.0002444311,0.00007018901,0.9454455,0.0009856581,0.0008273099,0.02215608],"study_design_scores_gemma":[0.0001185376,0.00357832,0.8646671,0.00008417605,0.0001240919,0.0111398,0.0003225223,0.0005526445,0.1105812,0.0009856891,0.007810516,0.00003539615],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924121,0.002597759,0.001798647,0.0001685977,0.0000470775,0.00005075206,0.0008250669,0.00004159728,0.002058323],"genre_scores_gemma":[0.9966187,0.000809308,0.0004722588,0.0001634623,0.00001356197,0.000057914,0.0004977313,0.00001940605,0.00134758],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00236612,"threshold_uncertainty_score":0.007915497,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03446327102258168,"score_gpt":0.2713620653176093,"score_spread":0.2368987942950276,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}