{"id":"W3170311810","doi":"10.2139/ssrn.3385124","title":"One Anti-CRISPR to Rule Them All: Potent Inhibition of Cas9 Homologs Used for Genome Editing","year":2019,"lang":"en","type":"article","venue":"SSRN Electronic Journal","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"Amgen (Canada); University of Toronto","funders":"","keywords":"CRISPR; Genome editing; Computational biology; Genome; Cas9; Genetics; Biology; Computer science; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004420086,0.0008552871,0.001084184,0.0004185195,0.0004482577,0.0009009251,0.0007702609,0.001064332,0.003090608],"category_scores_gemma":[0.0003446126,0.0004166549,0.0006510901,0.0002720358,0.0004218991,0.0003661907,0.0005717752,0.002256053,0.001902538],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004356042,"about_ca_system_score_gemma":0.0004606803,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006059316,"about_ca_topic_score_gemma":0.001420493,"domain_scores_codex":[0.9991912,0.00005164993,0.00009644013,0.0002760681,0.0003061344,0.00007847154],"domain_scores_gemma":[0.9996538,0.00005217079,0.00007140292,0.00007652902,0.00005908383,0.00008694622],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000968371,0.00005255245,0.0001072305,0.00004881722,0.00002174193,0.00006896508,0.00001167826,0.00008397114,0.9941967,0.0002254164,0.0003603747,0.004725841],"study_design_scores_gemma":[0.000009896438,0.0001343039,0.0002134821,0.000002726267,0.00002054965,0.0002705518,0.000004419251,0.0003388063,0.9950265,0.00004141357,0.003927019,0.00001039511],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8015581,0.00845731,0.1399876,0.001837249,0.001742152,0.0005932935,0.004373877,0.007126893,0.03432364],"genre_scores_gemma":[0.9173272,0.00305826,0.0492131,0.0008760892,0.00007078435,0.0001510868,0.002852339,0.0007520729,0.02569908],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003090608,"threshold_uncertainty_score":0.01033914,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00813783748958411,"score_gpt":0.2637757507930126,"score_spread":0.2556379133034284,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}