{"id":"W3170312846","doi":"10.21203/rs.3.rs-125972/v1","title":"Adenosine A1 Receptor Ligands Bind to α-Synuclein: Implications for α-Synuclein Misfolding and α-Synucleinopathy in Parkinson’s Disease","year":2020,"lang":"en","type":"preprint","venue":"Research Square","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Regina; University of Saskatchewan","funders":"Natural Sciences and Engineering Research Council of Canada; Saskatchewan Health Research Foundation; Heart and Stroke Foundation of Canada","keywords":"Parkinson's disease; Alpha-synuclein; Chemistry; Disease; Neuroscience; Biochemistry; Medicine; Biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002556757,0.000285008,0.0002955074,0.0002435095,0.0003594759,0.001173588,0.0002145501,0.0009311079,0.006135402],"category_scores_gemma":[0.0004800963,0.0002280061,0.0002645761,0.0002219437,0.0002194155,0.0005825274,0.0002033147,0.0006674636,0.002019597],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00043669,"about_ca_system_score_gemma":0.0001921524,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007901746,"about_ca_topic_score_gemma":0.0007935215,"domain_scores_codex":[0.9998865,0.00002381516,0.000004422088,0.0000224249,0.00003786457,0.00002493994],"domain_scores_gemma":[0.9999158,0.0000326624,0.00001583443,0.000007649001,0.00001136524,0.00001668046],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003094401,0.0003177372,0.004551073,0.000890528,0.0002299119,0.002715152,0.0004588056,0.003440508,0.8358151,0.04562955,0.03499887,0.06785848],"study_design_scores_gemma":[0.001021105,0.00135273,0.07833609,0.0003804267,0.0005990586,0.009492189,0.002042617,0.03469364,0.5344984,0.1283732,0.2090686,0.000141988],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8296921,0.06986541,0.008748004,0.01600156,0.00266046,0.00005999814,0.001291507,0.0003243888,0.07135656],"genre_scores_gemma":[0.9383339,0.02017837,0.002912262,0.001664968,0.0008086609,0.00003452592,0.000740554,0.00008094106,0.03524577],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006135402,"threshold_uncertainty_score":0.02052498,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09697680234136173,"score_gpt":0.3939336939123452,"score_spread":0.2969568915709835,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}