{"id":"W3170421887","doi":"10.1016/j.euros.2021.05.002","title":"Sexual Dimorphism in Outcomes of Non–muscle-invasive Bladder Cancer: A Role of CD163+ Macrophages, B cells, and PD-L1 Immune Checkpoint","year":2021,"lang":"en","type":"article","venue":"European Urology Open Science","topic":"Bladder and Urothelial Cancer Treatments","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Southeastern Ontario Academic Medical Organization; Ontario Ministry of Research and Innovation; Queen's University","keywords":"Immune system; Bladder cancer; Transcriptome; Immune checkpoint; Biology; CD163; Sexual dimorphism; Tumor microenvironment; Immunology; Cancer; Internal medicine; Oncology; Cancer research; Immunotherapy; Gene expression; Medicine; Gene; Endocrinology; Genetics; Phenotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007119562,0.0001924445,0.0005809542,0.0001539623,0.0001198228,0.0000237593,0.0006191665,0.00004280491,0.0002424645],"category_scores_gemma":[0.0001501405,0.0001602485,0.00005248921,0.0005639225,0.0009463048,0.0001783197,0.001253809,0.0001982613,0.00001799296],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004730202,"about_ca_system_score_gemma":0.0007208759,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00167738,"about_ca_topic_score_gemma":0.0002676862,"domain_scores_codex":[0.9980432,0.0001672274,0.0004953813,0.0006281385,0.0002984637,0.0003675837],"domain_scores_gemma":[0.9988251,0.00007615364,0.000205201,0.0005616784,0.0001835319,0.0001483521],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000182133,0.000366601,0.1188811,0.00004111385,0.00008908773,0.0004527787,0.002792582,0.00002398066,0.8699896,0.00004579506,0.00004169542,0.007093511],"study_design_scores_gemma":[0.002447361,0.0005504678,0.7791111,0.00003385243,0.00008808776,0.00005255336,0.0004981606,0.00004173242,0.2165104,0.00002963841,0.000519479,0.0001171254],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9856616,0.002335786,0.000007411914,0.0009930528,0.0001808017,0.0004222309,0.00004507557,0.00000902677,0.01034497],"genre_scores_gemma":[0.9972903,0.0003775731,0.0005457675,0.0006745168,0.00002709312,0.00001485048,0.000004788881,0.00002476777,0.001040315],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6602301,"threshold_uncertainty_score":0.6534746,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01738107776707242,"score_gpt":0.2941137366368099,"score_spread":0.2767326588697375,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}