{"id":"W3170449450","doi":"10.1200/jco.2021.39.15_suppl.501","title":"Breast Cancer Index (BCI) and prediction of benefit from extended aromatase inhibitor (AI) therapy (tx) in HR+ breast cancer: NRG oncology/NSABP B-42.","year":2021,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"National Institutes of Health","keywords":"Medicine; Breast cancer; Internal medicine; Letrozole; Cancer; Oncology; Proportional hazards model; Clinical endpoint; Aromatase inhibitor; Hazard ratio; Aromatase; Confidence interval; Randomized controlled trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[{"model":"gemma","categories":[],"domain":null,"study_design":"observational","genre":"empirical","about_ca_system":false,"about_ca_topic":false,"confidence":"low","status":"direct model label, unvalidated"},{"model":"gpt","categories":[],"domain":null,"study_design":"randomized_trial","genre":"empirical","about_ca_system":false,"about_ca_topic":false,"confidence":"medium","status":"direct model label, unvalidated"}],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002249906,0.0003034394,0.0004684589,0.000249853,0.0001031636,0.0002988934,0.0003051577,0.000320561,0.0008900316],"category_scores_gemma":[0.002578016,0.0001216147,0.0004526184,0.0003535095,0.0002039832,0.000226763,0.0003315519,0.000433677,0.0001901265],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003451866,"about_ca_system_score_gemma":0.0003300948,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001082093,"about_ca_topic_score_gemma":0.001802805,"domain_scores_codex":[0.9995087,0.0002646529,0.0000246104,0.00007320612,0.00009321056,0.00003550783],"domain_scores_gemma":[0.9986613,0.0006508406,0.0003674028,0.00005803358,0.00004866018,0.0002137231],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02561667,0.0002524266,0.9474065,0.0000876281,0.0005855573,0.00005811384,0.0000350928,0.0007766993,0.00154884,0.00003247436,0.0002499947,0.02334993],"study_design_scores_gemma":[0.0005932073,0.004446764,0.9884037,0.00001487676,0.0007116203,0.0002352361,0.00003154907,0.003919283,0.0008196916,0.00007387559,0.0007438866,0.000006307622],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976032,0.001498905,0.0001632553,0.00007858224,0.000008036398,0.00002283064,0.0002542908,0.000005832654,0.0003649956],"genre_scores_gemma":[0.9989873,0.0002025245,0.0002238518,0.00003041594,0.00001935406,0.00001392108,0.0003565672,0.000002142345,0.0001638714],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002249906,"threshold_uncertainty_score":0.01189882,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02615373624622831,"score_gpt":0.3787554359761841,"score_spread":0.3526016997299558,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}