{"id":"W3170450105","doi":"10.1200/jco.2021.39.15_suppl.2565","title":"Pembrolizumab in microsatellite instability high (MSI-H)/mismatch repair deficient (dMMR) cancers: Updated analysis from phase 2 KEYNOTE-158 study.","year":2021,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"","keywords":"Pembrolizumab; Medicine; Microsatellite instability; Internal medicine; Oncology; Cohort; Clinical endpoint; Response Evaluation Criteria in Solid Tumors; Discontinuation; Cancer; Phases of clinical research; Clinical trial; Immunotherapy; Allele; Microsatellite","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004421672,0.0006061878,0.001009237,0.0006559766,0.0001967898,0.0009453223,0.0007513987,0.0004047625,0.003242237],"category_scores_gemma":[0.002513886,0.0003466349,0.001213174,0.0009145105,0.0001247285,0.0007466107,0.0005065654,0.0008593693,0.0006463262],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007530783,"about_ca_system_score_gemma":0.001040309,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001022331,"about_ca_topic_score_gemma":0.003875223,"domain_scores_codex":[0.9992908,0.0002691706,0.00006615373,0.0001242617,0.0001669742,0.00008264572],"domain_scores_gemma":[0.9982454,0.0003804651,0.0007685325,0.000192049,0.0002293433,0.0001843409],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.1472572,0.002566969,0.3373316,0.005786809,0.01760568,0.0005637755,0.0002913373,0.00743762,0.03383611,0.0008620145,0.06062026,0.3858407],"study_design_scores_gemma":[0.06119867,0.03054269,0.7855063,0.001279456,0.01723345,0.002948944,0.0002071077,0.005170824,0.005657109,0.001063273,0.08905142,0.0001407322],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8786261,0.04760975,0.003217092,0.001203872,0.0001983041,0.002795698,0.05578385,0.0002830106,0.0102824],"genre_scores_gemma":[0.8922957,0.01251994,0.004784368,0.001779233,0.0002390176,0.001907291,0.08364372,0.00009945308,0.002731416],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004421672,"threshold_uncertainty_score":0.02338427,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09582486090055382,"score_gpt":0.465837091688276,"score_spread":0.3700122307877222,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}