{"id":"W3170458266","doi":"10.1093/neuonc/noab090.040","title":"EMBR-22. RATIONAL DEVELOPMENT OF SYNERGISTIC THERAPIES ALONGSIDE BMI1 INHIBITION FOR GROUP 3 MEDULLOBLASTOMA","year":2021,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; McMaster University","funders":"","keywords":"Medulloblastoma; Context (archaeology); BMI1; Biology; CRISPR; Cancer research; PI3K/AKT/mTOR pathway; Cancer; Gene; Signal transduction; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002706315,0.0001613013,0.0002773573,0.00004653235,0.0001441588,0.000009089864,0.00008987634,0.0001742177,0.00002885157],"category_scores_gemma":[0.0005821106,0.0001628302,0.00009691405,0.00008598208,0.0001283465,0.000003626861,0.0001188765,0.00007532244,0.000006053055],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004294419,"about_ca_system_score_gemma":0.0005527424,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001670797,"about_ca_topic_score_gemma":0.00009618313,"domain_scores_codex":[0.9986417,0.0001696716,0.0004329715,0.0003844194,0.0001352301,0.0002359629],"domain_scores_gemma":[0.9991017,0.0001915217,0.0001724358,0.0001823285,0.0003049982,0.00004702559],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000112532,0.0001637925,0.0001576259,0.00004575074,0.0001218589,0.0000281475,0.0003355692,0.00004431016,0.9885825,0.0004763771,0.001510087,0.008421475],"study_design_scores_gemma":[0.000839321,0.0005146856,0.0007230627,0.00001410416,0.00002797731,0.00004626439,0.0002403391,0.00002391815,0.8636292,0.0002033139,0.1335935,0.0001443108],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9759383,0.0008972147,0.02133984,0.0005032597,0.0004544343,0.0002509474,0.00003219112,0.0000187667,0.0005650679],"genre_scores_gemma":[0.98779,0.00003855374,0.01066785,0.0006734639,0.0002251312,0.0001743013,0.0003212924,0.00002674704,0.00008266189],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1320834,"threshold_uncertainty_score":0.6640021,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02209446757556258,"score_gpt":0.2825927927255436,"score_spread":0.260498325149981,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}