{"id":"W3170458266","doi":"10.1093/neuonc/noab090.040","title":"EMBR-22. RATIONAL DEVELOPMENT OF SYNERGISTIC THERAPIES ALONGSIDE BMI1 INHIBITION FOR GROUP 3 MEDULLOBLASTOMA","year":2021,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; McMaster University","funders":"","keywords":"Medulloblastoma; Context (archaeology); BMI1; Biology; CRISPR; Cancer research; PI3K/AKT/mTOR pathway; Cancer; Gene; Signal transduction; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001797028,0.0003392353,0.0003207514,0.0003705473,0.0001481154,0.0002974081,0.0003114933,0.0002559584,0.002515778],"category_scores_gemma":[0.0001163912,0.0001725383,0.0003765593,0.0002165009,0.0001772525,0.0001972407,0.0002791846,0.0006275167,0.0006210473],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004032408,"about_ca_system_score_gemma":0.0003842131,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008544563,"about_ca_topic_score_gemma":0.003050809,"domain_scores_codex":[0.9999191,0.000009658656,0.000004729779,0.0000180169,0.00003055455,0.00001798633],"domain_scores_gemma":[0.9999608,0.000004079074,0.00001196323,0.000003460868,0.000006530837,0.00001317744],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004814761,0.0002349013,0.0004368186,0.0003916601,0.00004233143,0.000216084,0.00004673626,0.002870698,0.9651351,0.001064324,0.001100177,0.02797962],"study_design_scores_gemma":[0.0002513716,0.003627905,0.003169616,0.00006720912,0.0001493178,0.0006951899,0.00005002142,0.00602179,0.936045,0.0004590239,0.04942422,0.00003939676],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.929224,0.01745378,0.02156013,0.0008733976,0.0002285,0.0008789107,0.004011974,0.001086912,0.02468232],"genre_scores_gemma":[0.9729398,0.006597065,0.01330613,0.0002262023,0.00001755027,0.0002566659,0.001386502,0.0000684636,0.005201611],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002515778,"threshold_uncertainty_score":0.008416176,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02209446757556258,"score_gpt":0.2825927927255436,"score_spread":0.260498325149981,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}