{"id":"W3170461786","doi":"10.1093/toxsci/kfab075","title":"2,3,7,8-Tetrachlorodibenzo-<i>p</i>-Dioxin (TCDD)-Inducible Poly-ADP-Ribose Polymerase (TIPARP/PARP7) Catalytic Mutant Mice (<i>TiparpH532A</i>) Exhibit Increased Sensitivity to TCDD-Induced Hepatotoxicity and Lethality","year":2021,"lang":"en","type":"article","venue":"Toxicological Sciences","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Aryl hydrocarbon receptor; Biology; Mutant; CYP1B1; Chemistry; Molecular biology; Gene; Biochemistry; Enzyme; Cytochrome P450; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001979179,0.0009758454,0.0004228564,0.0006775293,0.000212697,0.0003538663,0.0005307875,0.0007750981,0.002879008],"category_scores_gemma":[0.0001255721,0.0004601844,0.0006533961,0.0003567447,0.0006944726,0.0002513418,0.0002596556,0.001214434,0.00138707],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003840881,"about_ca_system_score_gemma":0.0001848454,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005420591,"about_ca_topic_score_gemma":0.0008000435,"domain_scores_codex":[0.9995003,0.00004518628,0.00005380157,0.0001681584,0.0001402629,0.0000923168],"domain_scores_gemma":[0.9995896,0.00003514877,0.0001821708,0.00005102609,0.00002788668,0.0001141788],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008027173,0.00003030898,0.0002060962,0.0000122965,0.000006274513,0.00004664203,0.000005229838,0.00003635639,0.9991333,0.00005193939,0.00003297652,0.0003582689],"study_design_scores_gemma":[0.00003244696,0.0005048183,0.004161071,0.00000560285,0.00002234618,0.0005146551,0.00002189823,0.0005197659,0.9929454,0.00004737661,0.001215736,0.000008975676],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9827484,0.0005961995,0.01097065,0.0001846676,0.0001179598,0.0001305789,0.002785263,0.0006480413,0.00181808],"genre_scores_gemma":[0.9789353,0.000814021,0.007869375,0.0001552237,0.0000267443,0.0002432565,0.0033784,0.0001852258,0.008392624],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002879008,"threshold_uncertainty_score":0.009631217,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06247968317217434,"score_gpt":0.3332812802719636,"score_spread":0.2708015970997892,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}