{"id":"W3170461786","doi":"10.1093/toxsci/kfab075","title":"2,3,7,8-Tetrachlorodibenzo-<i>p</i>-Dioxin (TCDD)-Inducible Poly-ADP-Ribose Polymerase (TIPARP/PARP7) Catalytic Mutant Mice (<i>TiparpH532A</i>) Exhibit Increased Sensitivity to TCDD-Induced Hepatotoxicity and Lethality","year":2021,"lang":"en","type":"article","venue":"Toxicological Sciences","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Aryl hydrocarbon receptor; Biology; Mutant; CYP1B1; Chemistry; Molecular biology; Gene; Biochemistry; Enzyme; Cytochrome P450; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.003369267,0.0006808819,0.001256823,0.0002730298,0.0008724151,0.0002723543,0.0003535177,0.0004851641,0.0009285915],"category_scores_gemma":[0.002232259,0.0005612465,0.0002893949,0.002240322,0.001130098,0.0004716373,0.0004456689,0.0008411866,0.0001757727],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004923758,"about_ca_system_score_gemma":0.001054688,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001469283,"about_ca_topic_score_gemma":0.0006513242,"domain_scores_codex":[0.9929851,0.0009942364,0.0009504942,0.002171519,0.001432845,0.001465775],"domain_scores_gemma":[0.9956499,0.001280642,0.000301881,0.0008641608,0.000312866,0.001590496],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004856249,0.001176868,0.01208962,0.00006242343,0.00005896613,0.001267419,0.0003103735,0.00001168891,0.9791957,0.0004722804,0.0005664532,0.004302564],"study_design_scores_gemma":[0.002203345,0.001286458,0.05339872,0.0001802551,0.0001035986,0.001339512,0.000495389,0.0004550786,0.9379537,0.000631691,0.001196775,0.0007555216],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9802351,0.0008979593,0.000273722,0.01184466,0.0004961026,0.001076777,0.0001809373,0.0003349273,0.004659825],"genre_scores_gemma":[0.9839599,0.00008731912,0.001936075,0.0130012,0.0005674631,0.0001230843,0.00002852925,0.00003483371,0.0002615839],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04130911,"threshold_uncertainty_score":0.9999847,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06247968317217434,"score_gpt":0.3332812802719636,"score_spread":0.2708015970997892,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}