{"id":"W3170470841","doi":"10.1016/s1474-4422(21)00159-9","title":"Safety, efficacy, and tolerability of efgartigimod in patients with generalised myasthenia gravis (ADAPT): a multicentre, randomised, placebo-controlled, phase 3 trial","year":2021,"lang":"en","type":"article","venue":"The Lancet Neurology","topic":"Myasthenia Gravis and Thymoma","field":"Medicine","cited_by":668,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; University Health Network","funders":"Argenx","keywords":"Tolerability; Medicine; Placebo; Myasthenia gravis; Adverse effect; Internal medicine; Physical therapy; Alternative medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006163692,0.0002346388,0.001510968,0.0000680471,0.00006003619,0.0000132198,0.0001392241,0.0001090011,0.0001144994],"category_scores_gemma":[0.0004159149,0.0001392068,0.0001168884,0.0001861739,0.0002194407,0.0000338863,0.00007715174,0.0003602125,0.000003311659],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001299988,"about_ca_system_score_gemma":0.00009847381,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004292265,"about_ca_topic_score_gemma":0.00009885576,"domain_scores_codex":[0.9974645,0.0007916183,0.0006522931,0.0004261018,0.0002602186,0.0004052633],"domain_scores_gemma":[0.9981815,0.0007032594,0.0002327578,0.0006364582,0.0001303476,0.0001156309],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9679277,0.001604116,0.0264818,0.00003716365,0.0001347522,0.00008492797,0.000356355,0.00004620661,0.000694429,0.0001547827,0.00008740353,0.002390368],"study_design_scores_gemma":[0.9169986,0.003121705,0.07734034,0.00002466416,0.0002241355,0.00003239385,0.00001048017,0.0009319719,0.0002627459,0.0001047741,0.0008278946,0.0001203051],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918201,0.0001765259,0.00002561926,0.004517586,0.0001442533,0.002970396,0.0000348816,0.00002402753,0.000286622],"genre_scores_gemma":[0.9981014,0.00004698849,0.0001374094,0.001321584,0.0001914228,0.00008693289,0.00003842335,0.0000243862,0.00005145203],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05092911,"threshold_uncertainty_score":0.5676688,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01486313727348669,"score_gpt":0.2664822666413657,"score_spread":0.2516191293678789,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}