{"id":"W3170470841","doi":"10.1016/s1474-4422(21)00159-9","title":"Safety, efficacy, and tolerability of efgartigimod in patients with generalised myasthenia gravis (ADAPT): a multicentre, randomised, placebo-controlled, phase 3 trial","year":2021,"lang":"en","type":"article","venue":"The Lancet Neurology","topic":"Myasthenia Gravis and Thymoma","field":"Medicine","cited_by":668,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; University Health Network","funders":"Argenx","keywords":"Tolerability; Medicine; Placebo; Myasthenia gravis; Adverse effect; Internal medicine; Physical therapy; Alternative medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001625889,0.002077859,0.003122035,0.0003350437,0.0004215472,0.001087835,0.0009056135,0.002113385,0.004720815],"category_scores_gemma":[0.001624658,0.0005531631,0.002165369,0.000389166,0.001408988,0.001106689,0.0004374664,0.00314411,0.0008758407],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007677444,"about_ca_system_score_gemma":0.000666845,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001026883,"about_ca_topic_score_gemma":0.002661,"domain_scores_codex":[0.9995388,0.0001938107,0.00002826662,0.00008798591,0.000043834,0.0001073461],"domain_scores_gemma":[0.9992224,0.0002345819,0.0001948528,0.00006804836,0.0000444144,0.0002356236],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9758158,0.00301049,0.001221161,0.0007409962,0.001649762,0.00008419865,0.00008259365,0.0002667661,0.002644185,0.00009930824,0.0009152413,0.01346944],"study_design_scores_gemma":[0.95094,0.04347159,0.004275344,0.00003178022,0.0004921461,0.0000511545,0.00002531605,0.000114401,0.0001155412,0.0001115326,0.0003551983,0.00001603206],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9869825,0.007884883,0.0002537481,0.0006599448,0.000374143,0.001161216,0.0007848666,0.00008632733,0.001812367],"genre_scores_gemma":[0.9899015,0.00295352,0.0006153708,0.001476982,0.000585835,0.001540981,0.0009847382,0.00001822875,0.001922817],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004720815,"threshold_uncertainty_score":0.01579267,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01486313727348669,"score_gpt":0.2664822666413657,"score_spread":0.2516191293678789,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}