{"id":"W3170485949","doi":"10.1096/fasebj.2021.35.s1.05240","title":"Tissue Specific Knockout of the Cardiolipin Transacylase Enzyme Tafazzin in Both Liver and Pancreatic Beta Cells Protects Mice From Diet‐Induced Obesity","year":2021,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Canadian Institutes of Health Research; Children's Hospital Research Institute of Manitoba; Heart and Stroke Foundation of Canada","keywords":"Allele; Biology; Cardiolipin; Genetically modified mouse; Cre recombinase; Transgene; Molecular biology; Endocrinology; Internal medicine; Genetics; Gene; Phospholipid; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003450556,0.0008940609,0.0005567301,0.001101678,0.0003480147,0.000664177,0.0007424601,0.0009712984,0.006034217],"category_scores_gemma":[0.0001638453,0.0007562026,0.0005267707,0.000462232,0.000515804,0.0004834484,0.0004791182,0.001750345,0.002806437],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003909255,"about_ca_system_score_gemma":0.0003474884,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006433924,"about_ca_topic_score_gemma":0.001273062,"domain_scores_codex":[0.9996004,0.00004099425,0.00004999266,0.0001005201,0.00009664555,0.000111518],"domain_scores_gemma":[0.9993359,0.00006127008,0.0002175495,0.0000774409,0.00004569737,0.0002619989],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003154745,0.00005054201,0.0001225077,0.00003362645,0.00001011119,0.00004132312,0.00001732347,0.00002879434,0.9980443,0.0002008696,0.0001138368,0.00102129],"study_design_scores_gemma":[0.0002620412,0.0008865481,0.007094251,0.00005224297,0.00009713982,0.0004492226,0.00007882317,0.0005986731,0.9802756,0.0001578208,0.01003012,0.00001765493],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9607602,0.003853329,0.01505324,0.0007180895,0.000295927,0.0002963688,0.006412331,0.001657875,0.01095249],"genre_scores_gemma":[0.9076447,0.004404668,0.01740654,0.0004711702,0.00012201,0.0008549669,0.005953904,0.0006695925,0.06247237],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006034217,"threshold_uncertainty_score":0.02018648,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01425582808821588,"score_gpt":0.2148396039785367,"score_spread":0.2005837758903208,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}