{"id":"W3170594626","doi":"10.1530/erc-21-0098","title":"Androgen receptor signaling inhibitors: post-chemotherapy, pre-chemotherapy and now in castration-sensitive prostate cancer","year":2021,"lang":"en","type":"review","venue":"Endocrine Related Cancer","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Terry Fox Foundation; National Cancer Institute; Dan L. Duncan Cancer Center, Baylor College of Medicine; Adrienne Helis Malvin Medical Research Foundation; Prostate Cancer Foundation","keywords":"Enzalutamide; Bicalutamide; Prostate cancer; Androgen receptor; Medicine; Flutamide; Abiraterone acetate; Cyproterone acetate; Androgen; Oncology; Internal medicine; Androgen deprivation therapy; Antiandrogen; Cancer; Pharmacology; Hormone","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006619238,0.0002750079,0.0006113362,0.0003912819,0.0002225933,0.0009536449,0.0003405417,0.0004473879,0.002154277],"category_scores_gemma":[0.0007248382,0.0001038623,0.0002671436,0.0006129129,0.0004243525,0.001051717,0.0003133711,0.001762788,0.0006983149],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005214891,"about_ca_system_score_gemma":0.000728098,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007048062,"about_ca_topic_score_gemma":0.003012918,"domain_scores_codex":[0.9998337,0.00002872258,0.00002218408,0.00003249614,0.00005292209,0.00002996478],"domain_scores_gemma":[0.9997062,0.00007291092,0.00005533003,0.00001557447,0.00007559264,0.00007445647],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"systematic_review","study_design_scores_codex":[0.001419066,0.0002580566,0.00279423,0.002255443,0.0000659626,0.0003570029,0.0001103141,0.0002371475,0.00351632,0.004104161,0.01659853,0.9682838],"study_design_scores_gemma":[0.0003872249,0.003867147,0.02044933,0.001960463,0.0003597329,0.004777649,0.0002059822,0.0004399112,0.004999525,0.004639644,0.9578532,0.00006031282],"study_design_candidate":"systematic_review","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01272315,0.9720225,0.0005405632,0.00700281,0.001543177,0.00002269866,0.0001134699,0.0000433089,0.005988365],"genre_scores_gemma":[0.1199951,0.8593225,0.001208695,0.008397614,0.002917695,0.00004263694,0.0004863562,0.00002414866,0.007605171],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002154277,"threshold_uncertainty_score":0.007206798,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02342480583172414,"score_gpt":0.3628771149748778,"score_spread":0.3394523091431537,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}