{"id":"W3170594626","doi":"10.1530/erc-21-0098","title":"Androgen receptor signaling inhibitors: post-chemotherapy, pre-chemotherapy and now in castration-sensitive prostate cancer","year":2021,"lang":"en","type":"review","venue":"Endocrine Related Cancer","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Terry Fox Foundation; National Cancer Institute; Dan L. Duncan Cancer Center, Baylor College of Medicine; Adrienne Helis Malvin Medical Research Foundation; Prostate Cancer Foundation","keywords":"Enzalutamide; Bicalutamide; Prostate cancer; Androgen receptor; Medicine; Flutamide; Abiraterone acetate; Cyproterone acetate; Androgen; Oncology; Internal medicine; Androgen deprivation therapy; Antiandrogen; Cancer; Pharmacology; Hormone","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002149889,0.0007990529,0.002277023,0.0004542486,0.0001144805,0.00008604772,0.0001118448,0.0003981161,0.001107699],"category_scores_gemma":[0.00003719162,0.0006250252,0.0003954264,0.001032997,0.000179634,0.0001639239,0.00007299555,0.001286212,0.00002175629],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001259348,"about_ca_system_score_gemma":0.00242954,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001259115,"about_ca_topic_score_gemma":0.0003461974,"domain_scores_codex":[0.9963403,0.0002569404,0.0009805706,0.001092037,0.0005074178,0.0008227663],"domain_scores_gemma":[0.9983612,0.0001701752,0.0003819661,0.0003942884,0.0003842778,0.000308038],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004988661,0.0002214944,0.001029813,0.00692523,0.002239763,0.0009967065,0.001383325,0.00001314646,0.0006965278,0.000008731032,0.002109102,0.9838773],"study_design_scores_gemma":[0.006530255,0.000430572,0.00009374824,0.04539239,0.0009749259,0.0004637523,0.0001849072,0.00001964797,0.004513409,0.000008960802,0.940568,0.0008193909],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01199715,0.9815074,5.578193e-7,0.002064161,0.000381209,0.00335753,0.0003930867,0.00008648083,0.0002124176],"genre_scores_gemma":[0.0003634308,0.9871846,0.0001205538,0.0002063513,0.0004878839,0.001252342,0.000921526,0.0002144165,0.009248886],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9830579,"threshold_uncertainty_score":0.9998055,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02342480583172414,"score_gpt":0.3628771149748778,"score_spread":0.3394523091431537,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}