{"id":"W3170603059","doi":"10.1038/s41467-021-24334-y","title":"Identification of 22 susceptibility loci associated with testicular germ cell tumors","year":2021,"lang":"en","type":"article","venue":"Nature Communications","topic":"Testicular diseases and treatments","field":"Medicine","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"National Center for Advancing Translational Sciences; National Institute of Environmental Health Sciences; National Cancer Institute; National Human Genome Research Institute; Strategic Research Council; Helse Sør-Øst RHF; National Institutes of Health; Yale University; Deutsche Krebshilfe; Børnecancerfonden; Fondazione Umberto Veronesi; University of Pennsylvania; Abramson Cancer Center; Novo Nordisk; Ministero dell’Istruzione, dell’Università e della Ricerca; Cancerfonden; Regione Piemonte; Dipartimenti di Eccellenza; University of Texas MD Anderson Cancer Center; Yale Cancer Center; Princess Margaret Cancer Foundation; Novo Nordisk Fonden; Wellcome Trust; Cancer Research UK; State of Connecticut Department of Public Health; Kreftforeningen; Horizon 2020 Framework Programme; Kræftens Bekæmpelse; National Institute of General Medical Sciences; Movember Foundation; Cancer Prevention and Research Institute of Texas","keywords":"Testicular Germ Cell Tumor; Testicular cancer; Genome-wide association study; Heritability; Seminoma; Biology; Somatic cell; Disease; Genetics; Cancer; Genetic association; Oncology; Internal medicine; Medicine; Gene; Genotype; Single-nucleotide polymorphism","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001427121,0.0007873395,0.0007427531,0.001987408,0.000423516,0.001196228,0.0004889966,0.000590758,0.002823002],"category_scores_gemma":[0.002605981,0.0003305373,0.002615338,0.002875627,0.0002676241,0.0001755613,0.0005808608,0.0005627045,0.0002320906],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000207195,"about_ca_system_score_gemma":0.0004306725,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00432967,"about_ca_topic_score_gemma":0.004481259,"domain_scores_codex":[0.9988833,0.0004185904,0.00008765802,0.0003072158,0.0001899669,0.0001133272],"domain_scores_gemma":[0.998105,0.0009036129,0.0005076065,0.0001804424,0.0001279884,0.0001752604],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001368777,0.00005000266,0.9580578,0.0003322233,0.01494105,0.001102525,0.00009841709,0.001088816,0.006783967,0.0002682929,0.0008561739,0.01505192],"study_design_scores_gemma":[0.0001807395,0.0002926647,0.9766799,0.0001316793,0.01421345,0.001288621,0.000132014,0.001849149,0.002391449,0.0005199685,0.002297469,0.00002284183],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9688966,0.02292784,0.003888898,0.0004253572,0.0001478941,0.00003459791,0.00211586,0.0001089092,0.001454039],"genre_scores_gemma":[0.9962513,0.001763306,0.0007573501,0.00006221492,0.00005486521,0.00001452223,0.000689177,0.00001313913,0.0003941163],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00432967,"threshold_uncertainty_score":0.009443879,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01385727718895686,"score_gpt":0.2940119587900782,"score_spread":0.2801546816011213,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}