{"id":"W3170606020","doi":"10.1093/ecco-jcc/jjab075.030","title":"OP31 RESTORE: Interim analysis of a Phase 2 study of QBECO SSI for the induction and maintenance of clinical and endoscopic remission in subjects with Moderate to Severe Crohn’s Disease","year":2021,"lang":"en","type":"article","venue":"Journal of Crohn s and Colitis","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Royal Columbian Hospital; Canadian Society of Intestinal Research","funders":"","keywords":"Medicine; Interim analysis; Internal medicine; Gastroenterology; Clinical endpoint; Clinical trial; Randomized controlled trial; Surgery","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006657245,0.001081486,0.002233329,0.0003729255,0.0004949122,0.001326111,0.000667422,0.001532969,0.004152119],"category_scores_gemma":[0.003949162,0.0004743286,0.002195581,0.0003934231,0.0008050542,0.001107035,0.0004911207,0.002113916,0.0007990436],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000589427,"about_ca_system_score_gemma":0.001895168,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009407072,"about_ca_topic_score_gemma":0.001729584,"domain_scores_codex":[0.9978849,0.001335361,0.0001088772,0.000179858,0.0001404114,0.0003506125],"domain_scores_gemma":[0.997318,0.0009322609,0.0006020742,0.0003521309,0.0002024047,0.0005932025],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.9623069,0.006879661,0.002943194,0.0003221917,0.00117354,0.00007154892,0.00006803457,0.000546462,0.004382838,0.00009368699,0.001461899,0.01975008],"study_design_scores_gemma":[0.5580946,0.4138296,0.02216049,0.00005611707,0.001304974,0.00007309204,0.00005835809,0.0009209688,0.001339898,0.0002696553,0.001858977,0.00003333993],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9837736,0.002266147,0.001733771,0.0005777606,0.0002615881,0.005222256,0.00319722,0.0001548077,0.002812879],"genre_scores_gemma":[0.9856511,0.0006669295,0.002066043,0.0006965134,0.0002038351,0.004204577,0.003236007,0.000033205,0.003241744],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006657245,"threshold_uncertainty_score":0.03520727,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02341021776307473,"score_gpt":0.3329091707668,"score_spread":0.3094989530037253,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}