{"id":"W3170616394","doi":"10.1038/s41375-021-01314-1","title":"Gene expression-based outcome prediction in advanced stage classical Hodgkin lymphoma treated with BEACOPP","year":2021,"lang":"en","type":"letter","venue":"Leukemia","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"Canadian Institutes of Health Research; BC Cancer Foundation; Max-Planck-Gesellschaft; Michael Smith Health Research BC","keywords":"Lymphoma; Classical Hodgkin lymphoma; Stage (stratigraphy); Oncology; Outcome (game theory); Internal medicine; Medicine; Hodgkin lymphoma; Gene expression; Cancer research; Gene; Biology; Genetics; Mathematics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00008876699,0.0007159536,0.001233081,0.0003285834,0.00008006398,0.00005497535,0.000153445,0.001139529,0.000405362],"category_scores_gemma":[0.00006095496,0.0005159256,0.0002872998,0.0004083257,0.00009951104,0.0000863979,0.00005291848,0.0007702645,0.00006605079],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.005560355,"about_ca_system_score_gemma":0.001530523,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002341918,"about_ca_topic_score_gemma":0.00005230792,"domain_scores_codex":[0.9965346,0.0001597045,0.0007108549,0.001100823,0.0008275915,0.0006663927],"domain_scores_gemma":[0.9981629,0.0002669677,0.0002619063,0.0009852614,0.0001201699,0.0002028462],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001608907,0.001079061,0.5498849,0.0007572419,0.0004125666,0.04956569,0.00007938035,0.0003748087,0.003016853,0.00000280359,0.3820489,0.01116888],"study_design_scores_gemma":[0.05092105,0.002487962,0.4015594,0.004079223,0.001055854,0.0003012379,0.00006165985,0.00125071,0.0771559,0.000004988339,0.4598829,0.001239106],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9135419,0.0008106948,0.00008928069,0.08022331,0.0004103615,0.001749598,0.0006256276,0.0003617501,0.002187512],"genre_scores_gemma":[0.51274,0.0001489528,0.008208445,0.4177506,0.003267845,0.002499447,0.01933718,0.0004873625,0.03556019],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4008019,"threshold_uncertainty_score":0.9997292,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01967995119461986,"score_gpt":0.2598461626357538,"score_spread":0.2401662114411339,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}