{"id":"W3170618908","doi":"10.1038/s42003-021-02889-2","title":"GFI1 tethers the NuRD complex to open and transcriptionally active chromatin in myeloid progenitors","year":2021,"lang":"en","type":"article","venue":"Communications Biology","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Centre Hospitalier Universitaire Sainte-Justine; Université Laval; Université de Montréal; Montreal Clinical Research Institute","funders":"Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Cancer Research Society","keywords":"Chromatin; Nucleosome; Chromatin remodeling; Cell biology; Chromodomain; Biology; Histone; Transcription factor; Enhancer; Promoter; Repressor; Myelopoiesis; DNA; Genetics; Gene; Progenitor cell; Gene expression; Helicase; Stem cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008562669,0.0001527691,0.0001178738,0.0001890028,0.0001757196,0.0002208134,0.000181807,0.0001446733,0.001072689],"category_scores_gemma":[0.0001037674,0.0001450156,0.00008884068,0.0000959462,0.000191725,0.0001089112,0.0003539263,0.0003514478,0.0004195297],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004603458,"about_ca_system_score_gemma":0.0001969815,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009758627,"about_ca_topic_score_gemma":0.001504139,"domain_scores_codex":[0.999917,0.000008730345,0.000003678206,0.00002083281,0.00002385493,0.00002589577],"domain_scores_gemma":[0.9999563,0.000005962432,0.00001074229,0.000005151327,0.0000039358,0.00001793717],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004976509,0.000005216916,0.0005403768,0.0000176069,0.000001255834,0.00004263857,0.00002049045,0.00003815814,0.99739,0.0001137574,0.00004484403,0.001735833],"study_design_scores_gemma":[0.00001423028,0.00009759912,0.02402614,0.000009801938,0.000007383469,0.0004114323,0.00006433092,0.001073112,0.9668256,0.0001316231,0.007335098,0.000003801909],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941485,0.001886922,0.00226718,0.00006990319,0.00001153794,0.00001119263,0.0001741138,0.00007411226,0.001356601],"genre_scores_gemma":[0.9918752,0.0008636182,0.001978465,0.00004174912,0.000006502999,0.00001689917,0.0005045378,0.00001942763,0.004693613],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001072689,"threshold_uncertainty_score":0.003588438,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.120600470919442,"score_gpt":0.4184278618639177,"score_spread":0.2978273909444757,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}