{"id":"W3170626123","doi":"10.1101/2021.06.04.447106","title":"The Rab GTPase activating protein TBC-2 regulates endosomal localization of DAF-16 FOXO and lifespan","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"National Institute of General Medical Sciences; Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; University of California, San Francisco; Directorate for Biological Sciences; National Institutes of Health; Oklahoma Medical Research Foundation; McGill University Health Centre; McGill University; Canadian Institutes of Health Research; Genome Canada; University of British Columbia; University of Pennsylvania; Vanderbilt University","keywords":"Rab; Endosome; Cell biology; GTPase; Small GTPase; Subcellular localization; Biology; Transport protein; Signal transduction; Cytoplasm","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001047616,0.0004161512,0.0002290557,0.0003703026,0.0002569859,0.0003559819,0.0001997754,0.0003961505,0.002331481],"category_scores_gemma":[0.0001038937,0.0002405573,0.0002334448,0.0001281534,0.0002627992,0.0002062619,0.0003938219,0.0004559046,0.0008512934],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005723494,"about_ca_system_score_gemma":0.0002767198,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001780951,"about_ca_topic_score_gemma":0.002126526,"domain_scores_codex":[0.9999146,0.000006431214,0.000004879329,0.0000244216,0.00002398449,0.00002560487],"domain_scores_gemma":[0.9999232,0.00000871457,0.00002281878,0.000009294499,0.00001318201,0.00002271153],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000812767,0.00001077258,0.000277577,0.00002446969,0.000002943721,0.00005594052,0.000006684207,0.00007328096,0.9983925,0.0002404326,0.0001477078,0.0006863431],"study_design_scores_gemma":[0.00002914498,0.00003897798,0.01102465,0.00001601699,0.00001117601,0.0002397324,0.00002868448,0.002828557,0.9812514,0.0001487282,0.004373351,0.000009525713],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9841051,0.002107398,0.00482308,0.0003631896,0.0001195507,0.00003092043,0.001156032,0.0003144661,0.006980246],"genre_scores_gemma":[0.9791324,0.0009048944,0.003456428,0.0001070219,0.00002045184,0.00003569328,0.001083149,0.0001697546,0.01509022],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002331481,"threshold_uncertainty_score":0.007799625,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007717678617832942,"score_gpt":0.2002817296874619,"score_spread":0.192564051069629,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}