{"id":"W3170700266","doi":"10.1016/j.ejmech.2021.113639","title":"Camptothecin's journey from discovery to WHO Essential Medicine: Fifty years of promise","year":2021,"lang":"en","type":"review","venue":"European Journal of Medicinal Chemistry","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":168,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Terry Fox Foundation","keywords":"Camptothecin; Irinotecan; Topotecan; Chemistry; Topoisomerase; Pharmacology; Natural product; Drug discovery; Prodrug; Cancer; Medicine; In vitro; Chemotherapy; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001747626,0.0007078349,0.001493544,0.00123697,0.0004717626,0.002087034,0.001139717,0.001842131,0.004171977],"category_scores_gemma":[0.001926665,0.0002639944,0.0004237193,0.001522992,0.001325727,0.003007092,0.001407338,0.004821366,0.001550447],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001516778,"about_ca_system_score_gemma":0.002805949,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00179458,"about_ca_topic_score_gemma":0.004528045,"domain_scores_codex":[0.99967,0.00006858265,0.00002926017,0.000044693,0.0001339883,0.00005347047],"domain_scores_gemma":[0.9991419,0.0004497939,0.00006349501,0.00002853556,0.0001719819,0.0001441835],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001734262,0.00009251477,0.0001225522,0.008547768,0.00008314748,0.000172535,0.0001756845,0.0002268356,0.001310172,0.02206307,0.1319701,0.8350621],"study_design_scores_gemma":[0.00002855434,0.00005655549,0.0001924565,0.002007839,0.00003513936,0.0002363032,0.00007473617,0.0000533151,0.0001524515,0.004246282,0.9929039,0.00001252205],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00006186784,0.9956862,0.0001055569,0.002557923,0.0008550576,0.000002704681,0.00001237738,0.0000083033,0.0007101011],"genre_scores_gemma":[0.0006640348,0.9964942,0.0001658513,0.001433142,0.0005775755,0.000004343029,0.00001962531,0.000002237961,0.0006389198],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004171977,"threshold_uncertainty_score":0.01395661,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02717497849165225,"score_gpt":0.3154622922771707,"score_spread":0.2882873137855185,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}