{"id":"W3170713734","doi":"10.1101/2021.06.03.446912","title":"An Alanine Aminotransferase is Required for Polysaccharide Regulation and Resistance of <i>Aspergillus fumigatus</i> Biofilms to Echinocandin Treatment","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Institute of Infection and Immunity; McGill University Health Centre","funders":"National Institute of Allergy and Infectious Diseases; Dartmouth College; National Institutes of Health; Cystic Fibrosis Foundation","keywords":"Echinocandin; Aspergillus fumigatus; Biofilm; Microbiology; Biology; Antifungal drug; Polysaccharide; Aspergillus; Antifungal; Biochemistry; Bacteria; Fluconazole","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001029133,0.0002918967,0.000302563,0.0001949079,0.000139236,0.0003992041,0.0001952777,0.0002654782,0.0006081754],"category_scores_gemma":[0.0002177297,0.0001457255,0.0002806326,0.0001390735,0.0001819253,0.0001349449,0.0002548977,0.0003429904,0.0003603651],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000384904,"about_ca_system_score_gemma":0.0001969379,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00245813,"about_ca_topic_score_gemma":0.001860772,"domain_scores_codex":[0.999783,0.00002915188,0.00003068248,0.00004245646,0.00006235597,0.00005247074],"domain_scores_gemma":[0.9997442,0.00003622173,0.0001014147,0.00003082001,0.00004271595,0.0000446863],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002899886,0.000009011866,0.0002737101,0.000008998306,0.000001963959,0.00002552345,0.000005684569,0.00001058848,0.9994316,0.00001415157,0.00001510803,0.0001747398],"study_design_scores_gemma":[0.000005788023,0.000101495,0.02623644,0.000006510331,0.00001145824,0.0003292624,0.00008361906,0.0007854109,0.9716408,0.00002981137,0.0007637842,0.000005645022],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967853,0.0007248133,0.001241575,0.0001098784,0.00001686624,0.00001542134,0.0004785967,0.00007707643,0.0005505193],"genre_scores_gemma":[0.9980288,0.0001379447,0.0006478182,0.00003263286,0.000003211274,0.00001228125,0.000531913,0.0000148482,0.0005904699],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00245813,"threshold_uncertainty_score":0.0048877,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01932058748773763,"score_gpt":0.2611807377570185,"score_spread":0.2418601502692809,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}