{"id":"W3170723526","doi":"10.1038/s41467-021-23610-1","title":"Chromosome compartments on the inactive X guide TAD formation independently of transcription during X-reactivation","year":2021,"lang":"en","type":"article","venue":"Nature Communications","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"The Scarborough Hospital","funders":"Agència de Gestió d'Ajuts Universitaris i de Recerca; National Institutes of Health; Generalitat de Catalunya; Ministerio de Asuntos Económicos y Transformación Digital, Gobierno de España; National Institute of General Medical Sciences; AXA Research Fund; Centres de Recerca de Catalunya; Agencia Estatal de Investigación; Ministerio de Ciencia, Innovación y Universidades","keywords":"XIST; Chromatin; X-inactivation; Biology; Reprogramming; X chromosome; Transcription (linguistics); Compartment (ship); Cell biology; Genetics; Chromosome; Molecular biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001314309,0.0001487687,0.0001170198,0.0001690941,0.0001267616,0.0005991357,0.0002063544,0.0001767898,0.001433129],"category_scores_gemma":[0.0001059343,0.000187082,0.0001700664,0.00008824273,0.0002347174,0.000266622,0.0004147761,0.0004362634,0.0005579423],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002071611,"about_ca_system_score_gemma":0.0001475112,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003025883,"about_ca_topic_score_gemma":0.0004758736,"domain_scores_codex":[0.9999133,0.000009088659,0.000007344976,0.00003133114,0.00002331094,0.00001550465],"domain_scores_gemma":[0.9998555,0.00003092841,0.0000349258,0.00003377772,0.00001263513,0.00003222951],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003634977,0.000004329669,0.0005004927,0.00001547254,0.00000197122,0.00003410573,0.00001532754,0.00005018073,0.9980697,0.0002779773,0.00001217174,0.0009817822],"study_design_scores_gemma":[0.000004497945,0.00004983496,0.01006669,0.000006100479,0.000005330847,0.0001864122,0.00002266363,0.0006081334,0.9868878,0.00007557729,0.002084782,0.000002254985],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9860427,0.001240924,0.009128905,0.00004888662,0.00001661064,0.00002330426,0.0004207012,0.0001807187,0.00289724],"genre_scores_gemma":[0.9922125,0.0004416834,0.002862369,0.00002592871,0.00000454757,0.00001784192,0.0004960906,0.00003900373,0.003900066],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001433129,"threshold_uncertainty_score":0.0047943,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01442041386079258,"score_gpt":0.2693884575394467,"score_spread":0.2549680436786542,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}