{"id":"W3170723526","doi":"10.1038/s41467-021-23610-1","title":"Chromosome compartments on the inactive X guide TAD formation independently of transcription during X-reactivation","year":2021,"lang":"en","type":"article","venue":"Nature Communications","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"The Scarborough Hospital","funders":"Agència de Gestió d'Ajuts Universitaris i de Recerca; National Institutes of Health; Generalitat de Catalunya; Ministerio de Asuntos Económicos y Transformación Digital, Gobierno de España; National Institute of General Medical Sciences; AXA Research Fund; Centres de Recerca de Catalunya; Agencia Estatal de Investigación; Ministerio de Ciencia, Innovación y Universidades","keywords":"XIST; Chromatin; X-inactivation; Biology; Reprogramming; X chromosome; Transcription (linguistics); Compartment (ship); Cell biology; Genetics; Chromosome; Molecular biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001104145,0.00008145068,0.00007952992,0.00002870449,0.0001864892,0.00001748927,0.0003522086,0.0001556831,0.000006923919],"category_scores_gemma":[0.00007849861,0.00007082365,0.00006087039,0.0001141311,0.00004482585,0.00001003602,0.0001134109,0.0002644531,0.000002986799],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005471458,"about_ca_system_score_gemma":0.00004959499,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006016967,"about_ca_topic_score_gemma":0.000194008,"domain_scores_codex":[0.999374,0.0001114578,0.0001998783,0.0001150225,0.00011811,0.00008153819],"domain_scores_gemma":[0.9986944,0.00003176197,0.0001470158,0.0009028546,0.0002051318,0.00001881153],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000164817,0.0001435095,0.0003383951,0.00001010908,0.00004692304,1.762667e-7,0.0001575605,0.0001004763,0.9934811,0.005164335,0.0003430373,0.0001979086],"study_design_scores_gemma":[0.0004878529,0.0000605922,0.0335074,0.00003666853,0.00002676448,0.00001361321,0.0006225648,0.0008660321,0.9514143,0.0003051223,0.01253571,0.0001233406],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937282,0.0006122453,0.0002726679,0.001378433,0.00006695241,0.0001755599,0.00004887598,0.000006744803,0.003710275],"genre_scores_gemma":[0.9975026,0.0005653743,0.0006863158,0.0001828396,0.00002600567,0.00002949837,0.0008668784,0.000009665143,0.0001308185],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04206675,"threshold_uncertainty_score":0.2888105,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01442041386079258,"score_gpt":0.2693884575394467,"score_spread":0.2549680436786542,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}