{"id":"W3170760961","doi":"10.3233/jhd-200463","title":"Reliable Resolution of Full-Length Huntingtin Alleles by Quantitative Immunoblotting","year":2021,"lang":"en","type":"article","venue":"Journal of Huntington s Disease","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Pacific Centre for Reproductive Medicine; BC Children's Hospital; University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Huntingtin; Huntingtin Protein; Mutant; Allele; Biology; Huntington's disease; Molecular biology; Genetics; Computational biology; Gene; Medicine; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002918267,0.001308733,0.0004828785,0.001465801,0.000503618,0.0008427407,0.001006371,0.0007565088,0.001846341],"category_scores_gemma":[0.002357874,0.0005504891,0.0005673465,0.0006408404,0.0006441124,0.0007188616,0.0005816078,0.001513688,0.001581064],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004818708,"about_ca_system_score_gemma":0.0005332868,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004023676,"about_ca_topic_score_gemma":0.001364817,"domain_scores_codex":[0.9979396,0.0004241477,0.0003236554,0.0004551293,0.0007104042,0.0001468446],"domain_scores_gemma":[0.997418,0.0007396902,0.0004462092,0.0005079983,0.0007723963,0.0001156795],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002128642,0.00004151129,0.0003012723,0.00007476344,0.00001044935,0.00001514767,0.00001876085,0.00004806782,0.9972602,0.0001442079,0.0001670985,0.001897134],"study_design_scores_gemma":[0.00001227392,0.00007957711,0.003067209,0.00002605162,0.00003318309,0.0001886557,0.00002091997,0.00158094,0.9913976,0.0002035894,0.003376254,0.00001363571],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.2928118,0.002994453,0.6881673,0.0006407481,0.0003549732,0.0008767499,0.004152454,0.003257181,0.00674431],"genre_scores_gemma":[0.3184831,0.003592919,0.6613421,0.000546993,0.0001199238,0.001616073,0.006200504,0.0011848,0.006913545],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.002918267,"threshold_uncertainty_score":0.01543349,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02509180781352066,"score_gpt":0.2820550171981764,"score_spread":0.2569632093846557,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}