{"id":"W3170764582","doi":"10.1200/jco.2021.39.15_suppl.tps9138","title":"An open-label, multicenter phase I/IIa study evaluating the safety and clinical activity of clonal neoantigen reactive T cells in patients with advanced non-small cell lung cancer (CHIRON).","year":2021,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Lung cancer; Cancer; Oncology; Chemotherapy; Immunotherapy; Immunology; Cancer research; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00138351,0.001017287,0.001101649,0.00031839,0.0003765835,0.000690607,0.000775224,0.001182528,0.006300449],"category_scores_gemma":[0.0007210084,0.0003841342,0.0008187153,0.0004041683,0.0008528373,0.0007216316,0.0003182237,0.002699662,0.001192938],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008318884,"about_ca_system_score_gemma":0.00134431,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008201267,"about_ca_topic_score_gemma":0.001795296,"domain_scores_codex":[0.9997032,0.0001310771,0.00001186311,0.00005964611,0.00003430415,0.00005981661],"domain_scores_gemma":[0.9994965,0.00007941731,0.00009673242,0.00004951113,0.00004275182,0.000235092],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.615993,0.101166,0.008076598,0.001573024,0.001207331,0.0004880483,0.0005207522,0.003770361,0.07401358,0.0006016921,0.01131794,0.1812717],"study_design_scores_gemma":[0.3486962,0.6351807,0.008099672,0.00005090126,0.0002404973,0.0003153527,0.00007826002,0.0007816484,0.002139028,0.0002267647,0.004172889,0.00001799421],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9875898,0.001940389,0.0008169728,0.0004628245,0.0002029913,0.004237955,0.001716714,0.0001142282,0.002918216],"genre_scores_gemma":[0.9782632,0.00194311,0.002248783,0.001431596,0.0001947428,0.006455428,0.004520182,0.00004742849,0.004895555],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006300449,"threshold_uncertainty_score":0.0210771,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1588071387751543,"score_gpt":0.5660918804300211,"score_spread":0.4072847416548668,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}