{"id":"W3170799867","doi":"10.1371/journal.pone.0253070","title":"Evaluation of liver enzyme elevations and hepatotoxicity in patients treated with checkpoint inhibitor immunotherapy","year":2021,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Toronto Liver Centre; University Health Network","funders":"Genentech; Servier; Astellas Pharma; Intercept Pharmaceuticals; EMD Serono; Mersana Therapeutics; Regeneron Pharmaceuticals; Array BioPharma; Gilead Sciences; PTC Therapeutics; Sanofi; GlaxoSmithKline; Amgen; Pfizer; MorphoSys; Celgene; Symphogen; AstraZeneca; Eli Lilly and Company; Bristol-Myers Squibb","keywords":"Medicine; Internal medicine; Cancer; Gastroenterology; Liver enzyme; Adverse effect","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001037753,0.0002123679,0.0005031643,0.000902619,0.0002939,0.0005461369,0.0001879547,0.0002572742,0.0009303866],"category_scores_gemma":[0.002314284,0.000137499,0.0003521132,0.001172458,0.0002689427,0.0003967295,0.0003245147,0.000501738,0.0001489279],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003392177,"about_ca_system_score_gemma":0.0003403247,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004978502,"about_ca_topic_score_gemma":0.0007565395,"domain_scores_codex":[0.9992604,0.0002308836,0.0001641623,0.0001143003,0.0001504081,0.00007983955],"domain_scores_gemma":[0.9968626,0.0004830275,0.002094195,0.0000769891,0.000222489,0.0002606401],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002481264,0.00001376351,0.9968946,0.00002614348,0.00002431227,0.0002220156,0.00001898857,0.00002878244,0.0001357814,0.000006830172,0.00005859781,0.002322014],"study_design_scores_gemma":[0.00002047945,0.0003919595,0.9944629,0.00003961211,0.00006920726,0.003918565,0.0001062032,0.0001948548,0.0003139141,0.00003230076,0.0004447012,0.000005378266],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939347,0.004045223,0.0002493493,0.00009826865,0.000009887852,0.00003443473,0.0004128554,0.00000952105,0.001205801],"genre_scores_gemma":[0.9986541,0.0006728047,0.0001736405,0.00005072137,0.00002045535,0.00001263638,0.0003349952,0.000001616262,0.00007901932],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001037753,"threshold_uncertainty_score":0.005488217,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04534679011720157,"score_gpt":0.255201225553827,"score_spread":0.2098544354366254,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}