{"id":"W3170835308","doi":"10.4049/jimmunol.2001173","title":"CD40L-Stimulated B Lymphocytes Are Polarized toward APC Functions after Exposure to IL-4 and IL-21","year":2021,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer; Centre Hospitalier de l’Université de Montréal","funders":"Natural Sciences and Engineering Research Council of Canada; Government of Canada","keywords":"CD40; B cell; Naive B cell; Cell biology; Biology; B-1 cell; Cytokine; Interleukin 21; Immune system; Antigen-presenting cell; T cell; Interleukin 4; Interleukin 12; Secretion; Immunology; Cytotoxic T cell; In vitro; Antibody; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009783979,0.0003331079,0.0001612237,0.0001901169,0.0001778704,0.0003180799,0.0001069251,0.000214685,0.001416335],"category_scores_gemma":[0.00009662131,0.000115264,0.0001948893,0.0001337854,0.0001380806,0.0001735604,0.000179793,0.0005090682,0.0004473481],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001485526,"about_ca_system_score_gemma":0.0001244875,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000265355,"about_ca_topic_score_gemma":0.0003700208,"domain_scores_codex":[0.9998543,0.00002666602,0.00001155465,0.00002295446,0.00003684683,0.0000476667],"domain_scores_gemma":[0.9999111,0.00002480378,0.00001534579,0.00001302581,0.00001178776,0.00002395528],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000712382,0.00001122325,0.0001412405,0.00001639516,0.000001401897,0.00003557824,0.00001359684,0.00001533419,0.9990754,0.00003366466,0.00001014473,0.0005747373],"study_design_scores_gemma":[0.00001185035,0.0001537158,0.007034908,0.00000654411,0.000008465615,0.000240136,0.00003848649,0.0003794505,0.9906539,0.00004822989,0.001421374,0.000002834915],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963217,0.0007964539,0.001170288,0.00003939605,0.00001366435,0.00001311044,0.0002173437,0.00002844346,0.001399698],"genre_scores_gemma":[0.9955134,0.0006135689,0.001099673,0.00003984318,0.00001652977,0.00004531527,0.0004712296,0.00001241895,0.002188142],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001416335,"threshold_uncertainty_score":0.004738092,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01108727558677388,"score_gpt":0.2142318313604199,"score_spread":0.203144555773646,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}