{"id":"W3170893157","doi":"10.1093/cdn/nzab049_038","title":"Methylenetetrahydrofolate Reductase Deficiency Reduces Brain Microglia in Zebrafish During Embryonic Development and Is Not Corrected by Folic Acid","year":2021,"lang":"en","type":"article","venue":"Current Developments in Nutrition","topic":"MicroRNA in disease regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"","keywords":"Zebrafish; Microglia; Biology; Methylenetetrahydrofolate reductase; Morpholino; Cell biology; Molecular biology; Genetics; Immunology; Gene; Allele; Inflammation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002247815,0.0004952425,0.0003943724,0.0004238829,0.0003179495,0.0003100844,0.0003859114,0.0006764715,0.002522341],"category_scores_gemma":[0.0001938496,0.0003402559,0.0005483447,0.0001254822,0.0004475675,0.0003279859,0.0003282364,0.001049157,0.0006084986],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00072668,"about_ca_system_score_gemma":0.0006283189,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006166516,"about_ca_topic_score_gemma":0.0111514,"domain_scores_codex":[0.9996855,0.00002247383,0.00002931799,0.00009318021,0.00009434766,0.00007517943],"domain_scores_gemma":[0.9997682,0.00002125298,0.00007954898,0.00001903801,0.00003489764,0.00007715866],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000123467,0.00002326545,0.0001440107,0.00005184508,0.000005383418,0.00007475358,0.00004331934,0.00003941003,0.9985066,0.000107432,0.0001022743,0.0007782259],"study_design_scores_gemma":[0.00006683282,0.0006968475,0.008201217,0.00004217376,0.00006318499,0.000280285,0.000127907,0.0009291884,0.9834936,0.0001351851,0.005942675,0.00002097388],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9848533,0.002446065,0.004679431,0.0005573295,0.0001365907,0.0001120645,0.002347603,0.0004091597,0.004458467],"genre_scores_gemma":[0.9658718,0.002245647,0.00612154,0.0003026825,0.00002473007,0.0003861118,0.001693614,0.0001883475,0.02316558],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006166516,"threshold_uncertainty_score":0.01226127,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01181652380100607,"score_gpt":0.2625970677334223,"score_spread":0.2507805439324162,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}