{"id":"W3170908410","doi":"10.1158/2159-8290.cd-21-0145","title":"Enhancer Hijacking Drives Oncogenic <i>BCL11B</i> Expression in Lineage-Ambiguous Stem Cell Leukemia","year":2021,"lang":"en","type":"article","venue":"Cancer Discovery","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":188,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research; National Cancer Institute; Ontario Institute for Cancer Research; National Institutes of Health; Canadian Cancer Society; Damon Runyon Cancer Research Foundation","keywords":"Enhancer; Stem cell; Biology; Cancer research; Leukemia; Lineage (genetic); Cell biology; Gene; Genetics; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002197468,0.0003164003,0.0005957993,0.0001485321,0.00008855013,0.0001125877,0.0002391477,0.0002348975,0.0004593224],"category_scores_gemma":[0.00004799918,0.0002865275,0.0002302144,0.0006084639,0.0001353194,0.0004536734,0.0003343156,0.0005965999,0.00009357944],"about_ca_system_candidate":true,"about_ca_system_consensus":true,"about_ca_system_score_codex":0.02468153,"about_ca_system_score_gemma":0.02082837,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001138034,"about_ca_topic_score_gemma":0.0003935287,"domain_scores_codex":[0.9970509,0.00009424562,0.0005269026,0.0008253632,0.0007361773,0.0007664555],"domain_scores_gemma":[0.9985182,0.0001430368,0.0001310262,0.0008188092,0.000146998,0.0002419839],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007327106,0.0003313429,0.003883614,0.001275835,0.0001024745,0.00307813,0.002212554,0.00186669,0.959223,0.00001852895,0.005692694,0.02158239],"study_design_scores_gemma":[0.01177418,0.00008190583,0.00156674,0.001565877,0.00007160339,0.00008967458,0.001082098,0.001874484,0.9746531,0.00001742586,0.006875809,0.0003471471],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9737403,0.01983321,0.000297006,0.0001631133,0.0006801297,0.0003900709,0.00002649167,0.00006699871,0.004802659],"genre_scores_gemma":[0.9665864,0.005645535,0.0002062104,0.0006728792,0.000685282,0.0001702474,0.00004974537,0.00008423987,0.02589949],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02123524,"threshold_uncertainty_score":0.9999587,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02139903256790399,"score_gpt":0.3059097712941333,"score_spread":0.2845107387262293,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}