{"id":"W3170908410","doi":"10.1158/2159-8290.cd-21-0145","title":"Enhancer Hijacking Drives Oncogenic <i>BCL11B</i> Expression in Lineage-Ambiguous Stem Cell Leukemia","year":2021,"lang":"en","type":"article","venue":"Cancer Discovery","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":188,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research; National Cancer Institute; Ontario Institute for Cancer Research; National Institutes of Health; Canadian Cancer Society; Damon Runyon Cancer Research Foundation","keywords":"Enhancer; Stem cell; Biology; Cancer research; Leukemia; Lineage (genetic); Cell biology; Gene; Genetics; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006556491,0.000129201,0.00007596848,0.0001317684,0.0001297446,0.0003666125,0.000130204,0.0001978496,0.001840546],"category_scores_gemma":[0.00007642181,0.00008630355,0.00006203511,0.0001001325,0.0002682196,0.0001222352,0.0002761829,0.0005462129,0.000543521],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002705204,"about_ca_system_score_gemma":0.0001361391,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003467648,"about_ca_topic_score_gemma":0.0005347963,"domain_scores_codex":[0.9999154,0.000008730414,0.000007120829,0.00001574727,0.00002780899,0.00002517254],"domain_scores_gemma":[0.9999381,0.0000117812,0.00002041079,0.000006660041,0.00000358625,0.00001946939],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008120121,0.00002132991,0.001485887,0.00001738261,0.000002501965,0.0003385091,0.00001953308,0.000104695,0.9946583,0.0006324075,0.0002386561,0.002399605],"study_design_scores_gemma":[0.00001793313,0.0001274249,0.02272571,0.000007134801,0.00001239663,0.003211586,0.0001193598,0.002745416,0.9617482,0.0003917035,0.008887199,0.000006041758],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929721,0.0006785913,0.002878395,0.0001781251,0.00003052349,0.00001699241,0.0003048403,0.0001852487,0.002755227],"genre_scores_gemma":[0.9972245,0.0002994172,0.000607301,0.00005489048,0.000009843,0.000006541812,0.0002822569,0.00001723331,0.00149813],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001840546,"threshold_uncertainty_score":0.006157219,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02139903256790399,"score_gpt":0.3059097712941333,"score_spread":0.2845107387262293,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}