{"id":"W3170999361","doi":"10.1200/jco.2021.39.15_suppl.2623","title":"Safety, pharmacokinetics, efficacy, and preliminary biomarker data of first-in-class BI 765063, a selective SIRPα inhibitor: Results of monotherapy dose escalation in phase 1 study in patients with advanced solid tumors.","year":2021,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Phagocytosis and Immune Regulation","field":"Immunology and Microbiology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"","keywords":"Medicine; Pharmacokinetics; Internal medicine; Adverse effect; Oncology; Pharmacodynamics; Anemia; Pharmacology; Gastroenterology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002403524,0.0001570508,0.001379997,0.0002845079,0.00002317257,0.00000316725,0.0002201276,0.0002764582,0.00001413103],"category_scores_gemma":[0.001741999,0.0001242761,0.00006931533,0.0003704962,0.0002220167,0.0002435545,0.0001545522,0.0005860673,5.499317e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009664,"about_ca_system_score_gemma":0.0004278211,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000352714,"about_ca_topic_score_gemma":0.0003089759,"domain_scores_codex":[0.9948507,0.00129905,0.003215822,0.0003295265,0.0001006757,0.0002042469],"domain_scores_gemma":[0.9948841,0.002241132,0.002194086,0.0002867519,0.0003582991,0.00003565076],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.1972681,0.03640517,0.5477804,0.00003366454,0.0005300851,0.00007959063,0.00117834,0.0006996637,0.02659865,0.000002581061,0.0002651245,0.1891586],"study_design_scores_gemma":[0.1130835,0.02088563,0.8586974,0.0002345686,0.00008098154,0.0000109798,0.000195561,0.0003609498,0.005661135,0.00001397913,0.0006739743,0.0001013718],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975382,0.001002614,0.00001649625,0.0003851803,0.0004681314,0.0004968435,0.00004687433,0.000002351423,0.0000433164],"genre_scores_gemma":[0.9989952,0.00065939,0.0001784523,0.00002908206,0.00002902605,0.000003302016,0.00008388153,0.00001245046,0.000009184496],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.310917,"threshold_uncertainty_score":0.5067834,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06246022385941271,"score_gpt":0.4158573951518553,"score_spread":0.3533971712924426,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}