{"id":"W3170999361","doi":"10.1200/jco.2021.39.15_suppl.2623","title":"Safety, pharmacokinetics, efficacy, and preliminary biomarker data of first-in-class BI 765063, a selective SIRPα inhibitor: Results of monotherapy dose escalation in phase 1 study in patients with advanced solid tumors.","year":2021,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Phagocytosis and Immune Regulation","field":"Immunology and Microbiology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"","keywords":"Medicine; Pharmacokinetics; Internal medicine; Adverse effect; Oncology; Pharmacodynamics; Anemia; Pharmacology; Gastroenterology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001548395,0.001054288,0.001283526,0.0003071357,0.0003020747,0.0007340498,0.000526059,0.0005919046,0.001603261],"category_scores_gemma":[0.0009327222,0.0003614337,0.000843086,0.0004375463,0.000460007,0.0004601822,0.0001975205,0.001667347,0.0005984112],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009072557,"about_ca_system_score_gemma":0.0007083693,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009756609,"about_ca_topic_score_gemma":0.001537374,"domain_scores_codex":[0.9995006,0.000229282,0.00003138949,0.00008150297,0.00007440638,0.0000829453],"domain_scores_gemma":[0.9990354,0.0002219523,0.0002794295,0.000105252,0.00006341073,0.0002947185],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.3369536,0.05230655,0.06102632,0.001103517,0.002782547,0.0008298185,0.001070377,0.02520895,0.2721013,0.0004008854,0.006417631,0.2397984],"study_design_scores_gemma":[0.05073112,0.7482657,0.1410451,0.00005293978,0.001417697,0.00188371,0.00015108,0.007117962,0.0430653,0.0002675401,0.005901229,0.0001007203],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963232,0.001447733,0.0005662778,0.0001039527,0.00001077718,0.000246283,0.0006655295,0.00005020512,0.0005860151],"genre_scores_gemma":[0.9953218,0.0007584062,0.0009001659,0.0001364201,0.00002454841,0.0001973827,0.001813703,0.00002720663,0.000820326],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001603261,"threshold_uncertainty_score":0.008188784,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06246022385941271,"score_gpt":0.4158573951518553,"score_spread":0.3533971712924426,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}