{"id":"W3171017049","doi":"10.1136/rmdopen-2021-001673","title":"Efficacy and safety of tofacitinib modified-release 11 mg once daily plus methotrexate in adult patients with rheumatoid arthritis: 24-week open-label phase results from a phase 3b/4 methotrexate withdrawal non-inferiority study (ORAL Shift)","year":2021,"lang":"en","type":"article","venue":"RMD Open","topic":"Rheumatoid Arthritis Research and Therapies","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Centre Hospitalier de l’Université de Montréal; Western University","funders":"Pfizer","keywords":"Medicine; Tofacitinib; Rheumatoid arthritis; Methotrexate; Internal medicine; Adverse effect; Placebo; Phases of clinical research; Open label; Clinical trial; Gastroenterology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002970565,0.001126736,0.00186566,0.0003516553,0.0003675082,0.0007080575,0.0005643885,0.001246819,0.002476882],"category_scores_gemma":[0.001728117,0.0003676676,0.001400879,0.0002852801,0.0006894673,0.0007471542,0.0002470347,0.002115766,0.0005304746],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004359523,"about_ca_system_score_gemma":0.000739462,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002826284,"about_ca_topic_score_gemma":0.0008018311,"domain_scores_codex":[0.9990426,0.0005128899,0.0001045427,0.0001048556,0.0001532701,0.00008180732],"domain_scores_gemma":[0.9983314,0.0004036649,0.000655596,0.0001118672,0.0001496653,0.0003477562],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8432779,0.02590864,0.00829655,0.001355991,0.002075083,0.0001777754,0.0002092529,0.0006175606,0.01932525,0.00007182014,0.00153685,0.09714743],"study_design_scores_gemma":[0.6165669,0.3541512,0.02412232,0.00006439417,0.0005979037,0.0003425383,0.00004442955,0.0004445352,0.002282668,0.00008289015,0.001268112,0.00003213842],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9900619,0.006645721,0.0004172004,0.0002402783,0.00007083727,0.001115549,0.0006916007,0.00004197722,0.0007150436],"genre_scores_gemma":[0.9915932,0.00242993,0.001262709,0.0005690443,0.0002956045,0.001274356,0.001471369,0.00001536644,0.001088294],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002970565,"threshold_uncertainty_score":0.01571,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04287122272998871,"score_gpt":0.3515452073586411,"score_spread":0.3086739846286524,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}