{"id":"W3171038570","doi":"10.1016/j.cmet.2021.05.017","title":"Leptin receptor-expressing pericytes mediate access of hypothalamic feeding centers to circulating leptin","year":2021,"lang":"en","type":"article","venue":"Cell Metabolism","topic":"Regulation of Appetite and Obesity","field":"Neuroscience","cited_by":51,"is_retracted":false,"has_abstract":false,"ca_institutions":"Douglas Mental Health University Institute; McGill University; McGill University Health Centre","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Leptin; Leptin receptor; Internal medicine; Endocrinology; Pericyte; Receptor; Biology; Adipokine; Paracellular transport; Hypothalamus; Medicine; Endothelial stem cell; In vitro; Obesity","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001490869,0.0002726793,0.0002189169,0.0002623128,0.0003521323,0.0004732176,0.0002016976,0.0002326265,0.0008952774],"category_scores_gemma":[0.0003519848,0.0001558248,0.0001566656,0.0001108019,0.0001557597,0.0005113461,0.0004254453,0.0004197513,0.0002461206],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002208871,"about_ca_system_score_gemma":0.000169121,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006616814,"about_ca_topic_score_gemma":0.001333595,"domain_scores_codex":[0.9998758,0.00002459586,0.000007710168,0.00001803774,0.00002465391,0.00004909894],"domain_scores_gemma":[0.9998172,0.00003715534,0.00003668683,0.00001490461,0.00003130289,0.00006275219],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003339636,0.00002081889,0.001235397,0.00008435214,0.00001476655,0.0004165756,0.000155558,0.00006345555,0.9876412,0.001315303,0.0001967612,0.008521918],"study_design_scores_gemma":[0.0001217654,0.000531751,0.09779665,0.0000622807,0.000116044,0.002310623,0.0009393295,0.003250341,0.8845764,0.001218308,0.009056057,0.00002045816],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9880449,0.003976267,0.00511987,0.0001538494,0.00006377945,0.00001314174,0.00008082757,0.00003607071,0.002511384],"genre_scores_gemma":[0.9926328,0.001575863,0.003054034,0.00004029899,0.00006598406,0.00002873219,0.00009745869,0.00001753538,0.002487166],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008952774,"threshold_uncertainty_score":0.002995074,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04003481415043669,"score_gpt":0.2809005705162118,"score_spread":0.2408657563657751,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}