{"id":"W3171058716","doi":"10.1093/neuonc/noab090.049","title":"EMBR-32. INTEGRATED STRESS RESPONSE PLAYS A PRO-SURVIVAL ROLE IN MYC-DRIVEN MEDULLOBLASTOMA","year":2021,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Cancer Research and Treatments","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; University of British Columbia Hospital","funders":"","keywords":"Integrated stress response; Unfolded protein response; Gene knockdown; Apoptosis; Translation (biology); Cancer research; Programmed cell death; Initiation factor; Cell biology; Endoplasmic reticulum; Messenger RNA; Biology; Chemistry; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001093684,0.0002403656,0.0001555578,0.0002187262,0.0001817535,0.0002209019,0.0001465341,0.0002007864,0.00320145],"category_scores_gemma":[0.00007304989,0.0001133788,0.0002262216,0.0001141259,0.0001674928,0.000142225,0.000172242,0.0004978008,0.000700436],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004446912,"about_ca_system_score_gemma":0.0002394783,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001116284,"about_ca_topic_score_gemma":0.001724021,"domain_scores_codex":[0.9999102,0.00001098948,0.000006433075,0.00001766434,0.00002981221,0.0000248651],"domain_scores_gemma":[0.9999439,0.000005011686,0.00001364765,0.000004948407,0.000005427314,0.00002706056],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002033137,0.00004580175,0.0005961738,0.00005377381,0.000005739638,0.0001595058,0.00001509346,0.00009070668,0.9968359,0.000175352,0.0001911162,0.001627635],"study_design_scores_gemma":[0.00008703726,0.0009070936,0.02733468,0.00002785961,0.00004387064,0.001686225,0.0001202468,0.003092803,0.9479179,0.0003114232,0.01846058,0.0000102845],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9889698,0.003027884,0.002467941,0.0002399355,0.00008059996,0.0000712339,0.001689281,0.0002035925,0.00324972],"genre_scores_gemma":[0.9939029,0.0006851938,0.0007068369,0.00004779041,0.000005094582,0.00004182689,0.001104968,0.000022604,0.003482806],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00320145,"threshold_uncertainty_score":0.01070994,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01527143674975315,"score_gpt":0.3108788137843365,"score_spread":0.2956073770345833,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}