{"id":"W3171065577","doi":"10.1096/fasebj.2021.35.s1.02498","title":"Inhibition of Elongation Factor 1A1 Activity Decreases Lipid Droplet Accumulation","year":2021,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Lipid metabolism and biosynthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; Western University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Lipotoxicity; Hepatocyte; Eukaryotic translation elongation factor 1 alpha 1; Internal medicine; Endocrinology; Cell biology; Lipid droplet; Hepatocyte growth factor; Fatty liver; Downregulation and upregulation; Chemistry; Cytoskeleton; Biology; Cell; Biochemistry; Insulin resistance; Medicine; Insulin; In vitro; Gene; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001384154,0.0004931251,0.0005640061,0.0003462937,0.000146176,0.0002258152,0.0002492808,0.0003740225,0.001409793],"category_scores_gemma":[0.0001371608,0.0001853945,0.0003236194,0.0002204478,0.0002276399,0.0002135497,0.0001846484,0.0009895072,0.0003010193],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002230443,"about_ca_system_score_gemma":0.000263279,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006969685,"about_ca_topic_score_gemma":0.001308098,"domain_scores_codex":[0.9998815,0.00001643511,0.0000146356,0.00002681153,0.00001983402,0.00004074201],"domain_scores_gemma":[0.9998637,0.00001825275,0.0000368945,0.00001098898,0.0000143727,0.00005560585],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002364293,0.0004023054,0.000397703,0.0001439637,0.00002699737,0.00004477595,0.00001830565,0.0001370851,0.992014,0.00007321435,0.0001997676,0.004177695],"study_design_scores_gemma":[0.0002228328,0.005166795,0.005740432,0.00002761596,0.00008000146,0.0001045621,0.00005377343,0.001201474,0.9830136,0.000078374,0.004296141,0.00001427664],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904732,0.005087745,0.001612636,0.0002421426,0.0001228223,0.00004011896,0.0006970503,0.0002648361,0.001459551],"genre_scores_gemma":[0.9893112,0.003719528,0.001965449,0.0001552612,0.00002838679,0.00009008243,0.001237687,0.00003786481,0.003454576],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001409793,"threshold_uncertainty_score":0.004716218,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02517285969726997,"score_gpt":0.2696634778959186,"score_spread":0.2444906181986486,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}