{"id":"W3171110834","doi":"10.1016/j.ymeth.2021.06.009","title":"Atrial-specific hiPSC-derived cardiomyocytes in drug discovery and disease modeling","year":2021,"lang":"en","type":"article","venue":"Methods","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; Simon Fraser University; BC Children's Hospital","funders":"Canadian Institutes of Health Research; Stem Cell Network","keywords":"Atrial fibrillation; Induced pluripotent stem cell; Drug discovery; Personalized medicine; Medicine; Cardiac electrophysiology; Mechanism (biology); Drug; Bioinformatics; Computational biology; Pharmacology; Biology; Internal medicine; Electrophysiology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006758483,0.0002996318,0.0002716512,0.0003338525,0.0001567375,0.0004851961,0.0004683979,0.0003855175,0.0009491366],"category_scores_gemma":[0.0003314732,0.0001791074,0.0002389526,0.0002288156,0.0003035042,0.0002373513,0.0004681993,0.000786665,0.0003325589],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001781984,"about_ca_system_score_gemma":0.0003141979,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004902558,"about_ca_topic_score_gemma":0.001011219,"domain_scores_codex":[0.9997546,0.00006464429,0.00001973848,0.00003846802,0.0001016627,0.00002081104],"domain_scores_gemma":[0.9998653,0.00003870634,0.00002134245,0.00002832675,0.00002162362,0.00002474544],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001586773,0.00006508172,0.0008957567,0.0002656189,0.00005322586,0.0002784209,0.00004934465,0.006069907,0.9500372,0.008564096,0.001227702,0.03233498],"study_design_scores_gemma":[0.00005149646,0.0002426912,0.001685933,0.00006901332,0.00008795796,0.0008056139,0.00004494638,0.02713484,0.9355277,0.002497486,0.03182742,0.00002475018],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.3541231,0.01615923,0.6037078,0.001409259,0.0006186567,0.0004102456,0.002878542,0.001401716,0.01929136],"genre_scores_gemma":[0.7994131,0.008622568,0.1826548,0.0004330704,0.0001233925,0.0003492555,0.001741463,0.0001569473,0.006505427],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.0009491366,"threshold_uncertainty_score":0.003574252,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03605825187450919,"score_gpt":0.34393076545107,"score_spread":0.3078725135765608,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}