{"id":"W3171136370","doi":"10.3389/fgene.2021.655882","title":"Murine Blastocysts Release Mature MicroRNAs Into Culture Media That Reflect Developmental Status","year":2021,"lang":"en","type":"article","venue":"Frontiers in Genetics","topic":"MicroRNA in disease regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children’s Health Research Institute; Western University","funders":"Robarts Research Institute; Lawson Health Research Institute; Canadian Institutes of Health Research; Academic Medical Organization of Southwestern Ontario; Natural Sciences and Engineering Research Council of Canada; Children's Health Research Institute","keywords":"Embryonic stem cell; Blastocyst; microRNA; Embryo; Biology; Zygote; Inner cell mass; Cell biology; Andrology; Embryogenesis; Genetics; Gene; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003862736,0.0006137965,0.0003845691,0.000379168,0.0001347372,0.0002711365,0.0002507764,0.0003103163,0.001445979],"category_scores_gemma":[0.0002270574,0.0002679037,0.0002977923,0.0001672018,0.0001990274,0.0001579336,0.0002211569,0.0006166209,0.001121703],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001608962,"about_ca_system_score_gemma":0.0002083741,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001678439,"about_ca_topic_score_gemma":0.0004540854,"domain_scores_codex":[0.9997004,0.00003502774,0.00003462266,0.00006600938,0.0001244967,0.00003939342],"domain_scores_gemma":[0.9997995,0.00005447055,0.00004169931,0.00003653772,0.00003578652,0.00003201877],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006813186,0.00001302607,0.0001559325,0.00001678419,0.000004353306,0.00002088515,0.00001254309,0.00001777121,0.9986259,0.00003608593,0.00002693322,0.001001788],"study_design_scores_gemma":[0.000007578991,0.0001821716,0.002403466,0.000005118166,0.0000133689,0.00005674997,0.000005572188,0.0002611325,0.9954615,0.00001589177,0.001584649,0.000002692525],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.940448,0.003236481,0.04473938,0.0001028516,0.000201344,0.0007187207,0.003741152,0.0007117084,0.006100405],"genre_scores_gemma":[0.8840252,0.003300972,0.07445884,0.0002756156,0.0001201386,0.001096044,0.0120048,0.0002570836,0.02446123],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001445979,"threshold_uncertainty_score":0.004837275,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007396685650966726,"score_gpt":0.2331261300422502,"score_spread":0.2257294443912835,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}