{"id":"W3171136370","doi":"10.3389/fgene.2021.655882","title":"Murine Blastocysts Release Mature MicroRNAs Into Culture Media That Reflect Developmental Status","year":2021,"lang":"en","type":"article","venue":"Frontiers in Genetics","topic":"MicroRNA in disease regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children’s Health Research Institute; Western University","funders":"Robarts Research Institute; Lawson Health Research Institute; Canadian Institutes of Health Research; Academic Medical Organization of Southwestern Ontario; Natural Sciences and Engineering Research Council of Canada; Children's Health Research Institute","keywords":"Embryonic stem cell; Blastocyst; microRNA; Embryo; Biology; Zygote; Inner cell mass; Cell biology; Andrology; Embryogenesis; Genetics; Gene; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00007761333,0.0002542938,0.0002065621,0.00007677067,0.00006854872,0.0000385654,0.000202061,0.0003305884,0.00003478565],"category_scores_gemma":[0.0001052785,0.0002715613,0.00009028568,0.0002209023,0.00008950225,0.000005263083,0.0002072955,0.000179702,0.000009928442],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001292739,"about_ca_system_score_gemma":0.0003652871,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005680054,"about_ca_topic_score_gemma":0.0001411582,"domain_scores_codex":[0.9984751,0.00009704105,0.0002622156,0.0005341933,0.0002198041,0.0004116251],"domain_scores_gemma":[0.9992153,0.000004791692,0.00009333979,0.0003818395,0.000115333,0.0001894086],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001648893,0.0001041506,0.03760083,0.000072101,0.0001006976,0.00008592017,0.0006495555,0.0001877636,0.8816757,0.00000527907,0.07400622,0.005346934],"study_design_scores_gemma":[0.0009715973,0.00004436785,0.02801779,0.0000470359,0.00003094787,0.00004797984,0.0006383233,0.00007003079,0.7540429,0.0002006781,0.2155078,0.0003805596],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9676895,0.02655004,0.003818563,0.00009721586,0.0009042185,0.0002391733,0.00006644982,0.00002030217,0.0006145776],"genre_scores_gemma":[0.8107585,0.003138672,0.1829109,0.0003520156,0.0003010746,0.00002613118,0.001574949,0.00006428717,0.0008734592],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1790923,"threshold_uncertainty_score":0.9999737,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007396685650966726,"score_gpt":0.2331261300422502,"score_spread":0.2257294443912835,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}