{"id":"W3171188620","doi":"10.1038/s41467-021-23892-5","title":"Hakai is required for stabilization of core components of the m6A mRNA methylation machinery","year":2021,"lang":"en","type":"article","venue":"Nature Communications","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":152,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Biotechnology and Biological Sciences Research Council; Hakai Institute; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Deutsche Forschungsgemeinschaft; Boehringer Ingelheim Fonds; Research Councils UK; Leverhulme Trust; National Science Foundation; Vallee Foundation; Agence Nationale de la Recherche; Howard Hughes Medical Institute; European Molecular Biology Organization; Université de Lausanne; Human Frontier Science Program; University of Cambridge","keywords":"Ubiquitin ligase; Ubiquitin; Methylation; Messenger RNA; Methyltransferase; Cell biology; N6-Methyladenosine; Function (biology); Biology; Translation (biology); Drosophila (subgenus); Chemistry; Biochemistry; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001168871,0.0003200617,0.0002596024,0.0002116225,0.0002654939,0.0004352752,0.0003661128,0.0003453222,0.001453614],"category_scores_gemma":[0.0002209389,0.0002413354,0.0002620524,0.0001132627,0.0003263219,0.0001575061,0.0003692778,0.0005243949,0.001028438],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003508118,"about_ca_system_score_gemma":0.0001787099,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007050789,"about_ca_topic_score_gemma":0.000745642,"domain_scores_codex":[0.9998242,0.00002710534,0.00002178515,0.00005021374,0.00003890377,0.00003779619],"domain_scores_gemma":[0.9995764,0.0000555425,0.0001476638,0.00006414356,0.00002806434,0.0001281127],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007221284,0.000009950883,0.0003478017,0.0000203208,0.000006272126,0.00007159309,0.000005924833,0.00004153594,0.9989457,0.00009262343,0.00003450617,0.0003516838],"study_design_scores_gemma":[0.0000136438,0.00005383465,0.0144361,0.000005484596,0.00001482052,0.0005936578,0.00002747846,0.002159948,0.9807737,0.00009130018,0.001822007,0.000007945147],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943838,0.0008137274,0.003368893,0.00009507895,0.00003890016,0.00001059149,0.0004417248,0.0001409813,0.0007064102],"genre_scores_gemma":[0.997579,0.0001164195,0.0008053294,0.00002074988,0.000004772913,0.000007012912,0.0003580529,0.00003596709,0.001072644],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001453614,"threshold_uncertainty_score":0.004862785,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0474161220309487,"score_gpt":0.335070230880104,"score_spread":0.2876541088491553,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}