{"id":"W3171188620","doi":"10.1038/s41467-021-23892-5","title":"Hakai is required for stabilization of core components of the m6A mRNA methylation machinery","year":2021,"lang":"en","type":"article","venue":"Nature Communications","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":152,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Biotechnology and Biological Sciences Research Council; Hakai Institute; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Deutsche Forschungsgemeinschaft; Boehringer Ingelheim Fonds; Research Councils UK; Leverhulme Trust; National Science Foundation; Vallee Foundation; Agence Nationale de la Recherche; Howard Hughes Medical Institute; European Molecular Biology Organization; Université de Lausanne; Human Frontier Science Program; University of Cambridge","keywords":"Ubiquitin ligase; Ubiquitin; Methylation; Messenger RNA; Methyltransferase; Cell biology; N6-Methyladenosine; Function (biology); Biology; Translation (biology); Drosophila (subgenus); Chemistry; Biochemistry; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000128659,0.00006028538,0.000091713,0.00001981883,0.0001197708,0.000005463862,0.0004460322,0.000159321,0.000008366723],"category_scores_gemma":[0.0002006884,0.00005016748,0.0001019432,0.0001886969,0.00009973814,0.000004390461,0.0001647768,0.0001121054,2.431716e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001257829,"about_ca_system_score_gemma":0.00008994521,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001113605,"about_ca_topic_score_gemma":0.0001194954,"domain_scores_codex":[0.9994281,0.0000783493,0.0002194527,0.0001220287,0.00009256851,0.00005948625],"domain_scores_gemma":[0.997762,0.000046035,0.0001950002,0.001444114,0.0005375753,0.00001524245],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000160941,0.0001057529,0.003806638,0.00002306095,0.00004241191,6.257277e-9,0.00009307107,0.00006903345,0.9870932,0.005468356,0.002107978,0.001174365],"study_design_scores_gemma":[0.0005708029,0.00004176985,0.04191814,0.00004306284,0.0000768249,0.000001808801,0.0001482493,0.002401908,0.8365838,0.001159444,0.1169296,0.0001246442],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.962432,0.02153682,0.006741903,0.005753071,0.0003031054,0.0006747933,0.0006966107,0.00001076929,0.001850902],"genre_scores_gemma":[0.9931099,0.0008037743,0.004500438,0.0002108248,0.0000227113,0.00003919792,0.001025708,0.000009873498,0.0002775834],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1505095,"threshold_uncertainty_score":0.2045771,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0474161220309487,"score_gpt":0.335070230880104,"score_spread":0.2876541088491553,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}