{"id":"W3171318868","doi":"10.1096/fasebj.27.1_supplement.990.1","title":"The amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD)‐associated C9ORF72 r(GGGGCC)n hexanucleotide repeat forms extremely stable uni‐and multi‐molecular RNA G‐quadruplex structures","year":2013,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Neurogenetic and Muscular Disorders Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Drug Policy Research Network; Hospital for Sick Children; University of Toronto","funders":"","keywords":"C9orf72; Frontotemporal dementia; RNA splicing; Amyotrophic lateral sclerosis; Myotonic dystrophy; Biology; Alternative splicing; Gene; Trinucleotide repeat expansion; Genetics; Molecular biology; RNA; Exon; Medicine; Disease; Dementia; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001193532,0.0002815878,0.00016461,0.0002425966,0.0002992218,0.0001915315,0.0001487051,0.0003343812,0.001642147],"category_scores_gemma":[0.0001956788,0.00008848448,0.0001557238,0.0001401173,0.0002041253,0.0001138521,0.0002256451,0.000252999,0.0005195895],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004161875,"about_ca_system_score_gemma":0.0001687856,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001471898,"about_ca_topic_score_gemma":0.002684871,"domain_scores_codex":[0.9998709,0.00001651555,0.000009682759,0.00004048876,0.00003988062,0.00002246256],"domain_scores_gemma":[0.9998811,0.00001671305,0.00005327823,0.00001048434,0.00001025347,0.00002815639],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001935616,0.00002520128,0.00259292,0.00005161221,0.00001159532,0.0007512193,0.00002345831,0.00006939098,0.9883021,0.0001781458,0.0002334364,0.007567391],"study_design_scores_gemma":[0.00004815264,0.0006478722,0.1815914,0.0000232807,0.00006325731,0.01854289,0.0001153735,0.00185526,0.7796769,0.0006214273,0.01678258,0.00003156109],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922175,0.00303242,0.001966444,0.0001735959,0.00003577932,0.00001527197,0.0003306262,0.00009432098,0.002134115],"genre_scores_gemma":[0.9955115,0.0006522154,0.001270033,0.00006771145,0.00001702029,0.00001628339,0.0005204427,0.00000636958,0.001938535],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001642147,"threshold_uncertainty_score":0.005493522,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02838446629443742,"score_gpt":0.257027191872548,"score_spread":0.2286427255781106,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}