{"id":"W3171334864","doi":"10.1200/jco.2021.39.15_suppl.4527","title":"Avelumab first-line (1L) maintenance for advanced urothelial carcinoma (UC) in the JAVELIN Bladder 100 trial: Subgroup analysis by duration of treatment-free interval (TFI) from end of chemotherapy to start of maintenance.","year":2021,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Bladder and Urothelial Cancer Treatments","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Medicine; Avelumab; Chemotherapy; Hazard ratio; Internal medicine; Metastatic Urothelial Carcinoma; Urology; Gastroenterology; Neutropenia; Intention-to-treat analysis; Post-hoc analysis; Surgery; Urothelial carcinoma; Bladder cancer; Oncology; Randomized controlled trial; Pembrolizumab; Immunotherapy; Cancer; Confidence interval","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002671073,0.0007401434,0.002139478,0.0002840065,0.0001940825,0.0009364858,0.0005097922,0.0008176718,0.002458229],"category_scores_gemma":[0.002207511,0.0003176199,0.003860344,0.0003917087,0.0003788847,0.0006275959,0.0004191391,0.001349394,0.0002237056],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004178751,"about_ca_system_score_gemma":0.0005699481,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004344383,"about_ca_topic_score_gemma":0.001710859,"domain_scores_codex":[0.9990244,0.0006178896,0.00007584289,0.0001263466,0.00005221387,0.0001034015],"domain_scores_gemma":[0.9991061,0.0003485866,0.0002289455,0.0001051547,0.00002905491,0.0001821788],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.9553226,0.001310765,0.007717801,0.001503934,0.008375187,0.00007917499,0.00006623765,0.0006850319,0.003113428,0.0001468826,0.001064044,0.02061492],"study_design_scores_gemma":[0.7843446,0.1202777,0.05536461,0.0004554035,0.02884419,0.0003578057,0.0001503517,0.003201718,0.00171829,0.001230967,0.003972264,0.00008217586],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.979198,0.01581647,0.0006383734,0.000504273,0.000238487,0.0008521145,0.001105936,0.00005040594,0.001595911],"genre_scores_gemma":[0.9942016,0.002134941,0.0004720318,0.0003739071,0.0001490618,0.0008617963,0.000946683,0.00001321776,0.0008467677],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002671073,"threshold_uncertainty_score":0.01412618,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07614720092709548,"score_gpt":0.408757623807723,"score_spread":0.3326104228806275,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}