{"id":"W3171352936","doi":"10.3390/molecules26123529","title":"Functional Domains and Evolutionary History of the PMEL and GPNMB Family Proteins","year":2021,"lang":"en","type":"article","venue":"Molecules","topic":"Genomics and Phylogenetic Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Alberta Innovates; Foundation Fighting Blindness","keywords":"Biology; Genetics; Gene; Functional divergence; Gene family; Evolutionary biology; Gene duplication; Phenotype; Phylogenetics; Genome","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000176554,0.0002147556,0.0002131876,0.001503266,0.0006522714,0.0004017079,0.0002672707,0.0004010346,0.001423305],"category_scores_gemma":[0.0003747563,0.0001335239,0.0002639946,0.0006878466,0.0004846816,0.0005664317,0.0005441974,0.00038536,0.0006935142],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002641459,"about_ca_system_score_gemma":0.0001583559,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008518026,"about_ca_topic_score_gemma":0.001222587,"domain_scores_codex":[0.9998733,0.000014573,0.000006053589,0.00006103702,0.00002664636,0.00001834678],"domain_scores_gemma":[0.9998102,0.00003714034,0.00006048553,0.00001912598,0.00003767488,0.00003548251],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0004639488,0.00005158428,0.1555951,0.000403216,0.0001181594,0.001675818,0.002649146,0.0008021264,0.7681128,0.00248163,0.0004307696,0.06721562],"study_design_scores_gemma":[0.0000146528,0.0001992027,0.9423754,0.00009193519,0.00009011737,0.009335625,0.001155171,0.002924308,0.01627338,0.001118166,0.02637581,0.00004618614],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921126,0.002917493,0.002152317,0.00007140393,0.000008438256,0.000008439528,0.0003451741,0.00004284103,0.002341281],"genre_scores_gemma":[0.9931444,0.001531888,0.00303366,0.00006774909,0.00001921816,0.00001592768,0.0009865871,0.00003555353,0.001165116],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001503266,"threshold_uncertainty_score":0.004761398,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0101606526142824,"score_gpt":0.1818347787798957,"score_spread":0.1716741261656133,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}