{"id":"W3171352936","doi":"10.3390/molecules26123529","title":"Functional Domains and Evolutionary History of the PMEL and GPNMB Family Proteins","year":2021,"lang":"en","type":"article","venue":"Molecules","topic":"Genomics and Phylogenetic Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Alberta Innovates; Foundation Fighting Blindness","keywords":"Biology; Genetics; Gene; Functional divergence; Gene family; Evolutionary biology; Gene duplication; Phenotype; Phylogenetics; Genome","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00003167554,0.00006883002,0.00006877977,0.000008886507,0.00005097175,0.000003104165,0.00004030237,0.00004535306,0.000003858018],"category_scores_gemma":[0.00002201657,0.00005538382,0.0000361237,0.00002110644,0.0001700746,3.457025e-7,0.0001714013,0.00003108145,3.373185e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001253268,"about_ca_system_score_gemma":0.0001145648,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001882223,"about_ca_topic_score_gemma":0.00002570249,"domain_scores_codex":[0.9995813,0.00002994264,0.00008164338,0.0001679418,0.00006329709,0.00007588604],"domain_scores_gemma":[0.9997355,0.000005930706,0.00003314544,0.0001441899,0.00005825188,0.00002298941],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00001283177,0.00002038312,0.008560417,0.00001326028,0.00004168228,0.000001251992,0.00004400144,0.0000135484,0.9876021,0.0005583448,0.002743192,0.000388976],"study_design_scores_gemma":[0.0003616121,0.00007319913,0.8752681,0.000009932769,0.00002511011,0.00003483097,0.000136567,0.00002034421,0.06152759,0.0007972425,0.06162529,0.0001202002],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9657176,0.03233306,0.0001606812,0.0002278706,0.0001258907,0.00006861721,0.00001929769,0.0000010206,0.00134602],"genre_scores_gemma":[0.9967119,0.0006085845,0.0008481792,0.0002669054,0.00005048021,0.0000123355,0.00000889348,0.000007034655,0.001485741],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9260745,"threshold_uncertainty_score":0.2258487,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0101606526142824,"score_gpt":0.1818347787798957,"score_spread":0.1716741261656133,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}