{"id":"W3171383385","doi":"10.1038/s41541-021-00345-0","title":"Messenger RNA expressing PfCSP induces functional, protective immune responses against malaria in mice","year":2021,"lang":"en","type":"article","venue":"npj Vaccines","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":84,"is_retracted":false,"has_abstract":true,"ca_institutions":"Acuitas Therapeutics (Canada)","funders":"Leids Universitair Medisch Centrum; U.S. Military Academy; United States Agency for International Development; Universiteit Leiden; U.S. Department of Defense","keywords":"Circumsporozoite protein; Malaria; Malaria vaccine; Virology; Plasmodium falciparum; Plasmodium berghei; Vaccination; Adjuvant; Immune system; Biology; Immunology; Population; Medicine; Environmental health","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004184794,0.0005196052,0.0003074912,0.0004533585,0.0001697343,0.000298563,0.0002908547,0.0005124493,0.001113904],"category_scores_gemma":[0.0001895662,0.0002671202,0.0002775257,0.000172855,0.0004174803,0.0002816001,0.0001550956,0.001330841,0.0005554776],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003193162,"about_ca_system_score_gemma":0.0003000091,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003965814,"about_ca_topic_score_gemma":0.0006547712,"domain_scores_codex":[0.9997149,0.00004045805,0.0000247159,0.00007957744,0.0000730838,0.00006733848],"domain_scores_gemma":[0.999803,0.00002935605,0.00006750838,0.00002703939,0.00002820003,0.00004496839],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001685106,0.00009462926,0.00005253622,0.00004241937,0.000003129355,0.00002753354,0.00002438218,0.00006899858,0.9982983,0.0001550079,0.00006457218,0.001000015],"study_design_scores_gemma":[0.00006804842,0.001903129,0.001242535,0.00001741132,0.00001671962,0.0001627915,0.00002833374,0.0009833277,0.9922494,0.0001222924,0.003200005,0.000006201362],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9806383,0.001412101,0.01070287,0.000453856,0.0001383599,0.0001700952,0.001031358,0.0005396149,0.004913438],"genre_scores_gemma":[0.9782459,0.001718044,0.008740413,0.0003155744,0.00005603103,0.0002380255,0.001170624,0.0001299876,0.009385459],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001113904,"threshold_uncertainty_score":0.003726363,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02076743166818817,"score_gpt":0.2596979826707817,"score_spread":0.2389305510025935,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}