{"id":"W3171383385","doi":"10.1038/s41541-021-00345-0","title":"Messenger RNA expressing PfCSP induces functional, protective immune responses against malaria in mice","year":2021,"lang":"en","type":"article","venue":"npj Vaccines","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":84,"is_retracted":false,"has_abstract":true,"ca_institutions":"Acuitas Therapeutics (Canada)","funders":"Leids Universitair Medisch Centrum; U.S. Military Academy; United States Agency for International Development; Universiteit Leiden; U.S. Department of Defense","keywords":"Circumsporozoite protein; Malaria; Malaria vaccine; Virology; Plasmodium falciparum; Plasmodium berghei; Vaccination; Adjuvant; Immune system; Biology; Immunology; Population; Medicine; Environmental health","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001508332,0.0001592084,0.000162786,0.00007243223,0.00007984853,0.00004795425,0.0001269778,0.0001438969,0.00007774423],"category_scores_gemma":[0.00025478,0.0001508313,0.00007881933,0.0001495818,0.00001821543,0.00001415068,0.0001300442,0.0001455999,0.00001842769],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001567876,"about_ca_system_score_gemma":0.0001464559,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002749682,"about_ca_topic_score_gemma":0.00007728112,"domain_scores_codex":[0.9989454,0.000138578,0.0002308586,0.0003839551,0.00009577121,0.0002054419],"domain_scores_gemma":[0.9994024,0.00002897455,0.00007511591,0.0002522094,0.0002053428,0.00003594902],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003323592,0.00006600384,0.0009940455,0.00001443644,0.000046467,0.00002794258,0.00007934599,0.00007157932,0.9957795,0.000006745029,0.000956369,0.001625236],"study_design_scores_gemma":[0.0004638298,0.00008703273,0.06620778,0.0000693675,0.000008769836,0.00001916809,0.0004374222,0.0000166369,0.9306764,0.00005108422,0.001781868,0.0001806214],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943733,0.003687742,0.0001046753,0.0004576043,0.00026526,0.0001290745,0.000009825375,0.00001263262,0.000959836],"genre_scores_gemma":[0.9966086,0.0003042942,0.0002241381,0.0002967826,0.0002799212,0.00005539439,0.00008029391,0.00001848795,0.002132134],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06521373,"threshold_uncertainty_score":0.6150723,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02076743166818817,"score_gpt":0.2596979826707817,"score_spread":0.2389305510025935,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}