{"id":"W3171393216","doi":"10.1200/jco.2021.39.15_suppl.6059","title":"Prospective manipulation of the gut microbiome with Microbial Ecosystem Therapeutic 4 (MET4) in locoregionally advanced oropharyngeal squamous cell carcinoma (LA-OPSCC) undergoing primary chemoradiation (ROMA2).","year":2021,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Head and Neck Cancer Studies","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University of Guelph; Toronto General Hospital; University Health Network; Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Internal medicine; Adverse effect; Interquartile range; Oncology; Gastroenterology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005590493,0.000243715,0.0004438956,0.0001360611,0.0003706233,0.0004290737,0.0001931787,0.0004090963,0.001988163],"category_scores_gemma":[0.0006335865,0.0002210804,0.0005265983,0.0002289634,0.0002534515,0.0002987535,0.0004291129,0.0006343694,0.0003797963],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005428326,"about_ca_system_score_gemma":0.0006941709,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001061521,"about_ca_topic_score_gemma":0.0019743,"domain_scores_codex":[0.9997756,0.00007353499,0.00001076011,0.00006296791,0.00002893375,0.00004825431],"domain_scores_gemma":[0.9996635,0.00004689708,0.00008665402,0.00003063073,0.00004254509,0.0001297926],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.1871604,0.01876439,0.5763943,0.00068291,0.0008043355,0.000449326,0.0005716583,0.000935048,0.1047407,0.000139857,0.003239147,0.106118],"study_design_scores_gemma":[0.004859365,0.1925834,0.7798953,0.00006795286,0.0007038825,0.0006305652,0.0005445423,0.001603866,0.01377967,0.0001677297,0.005125418,0.00003830983],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990067,0.0002351547,0.0001159244,0.00004431999,0.000009271998,0.0000919185,0.0003118642,0.000007574704,0.0001773036],"genre_scores_gemma":[0.9975344,0.0001680509,0.0004207599,0.0001220477,0.00001473514,0.0002047805,0.0009815029,0.000007054992,0.0005466594],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001988163,"threshold_uncertainty_score":0.006651103,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04276970624319562,"score_gpt":0.3496313950268305,"score_spread":0.306861688783635,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}