{"id":"W3171403924","doi":"10.1007/s00217-021-03770-6","title":"Characterization of β-secretase inhibitory extracts from sea cucumber (Stichopus japonicus) hydrolysis with their cellular level mechanism in SH-SY5Y cells","year":2021,"lang":"en","type":"article","venue":"European Food Research and Technology","topic":"Protein Hydrolysis and Bioactive Peptides","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"Korea Institute of Marine Science and Technology promotion; Ministry of Oceans and Fisheries","keywords":"Hydrolysate; Chemistry; Fucose; Biochemistry; Trypsin; Galactose; Hydrolysis; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001052193,0.0004129585,0.0002085116,0.0001811167,0.0001439993,0.000204784,0.000134848,0.0001327929,0.0008184735],"category_scores_gemma":[0.00008365033,0.0001006834,0.0002800849,0.0001767684,0.0001431774,0.0001960267,0.0001269371,0.0003958551,0.0002752416],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001360158,"about_ca_system_score_gemma":0.0001320834,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001016629,"about_ca_topic_score_gemma":0.001272163,"domain_scores_codex":[0.9999385,0.000006787659,0.000007682371,0.00001414927,0.00001878653,0.00001409383],"domain_scores_gemma":[0.9999369,0.00001292541,0.00001418505,0.000008505453,0.00001334413,0.00001405035],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005791692,0.00001006953,0.000117146,0.00002097746,0.00000349696,0.00003483029,0.00001003555,0.0000109843,0.9993225,0.00002134293,0.000009723177,0.0003810297],"study_design_scores_gemma":[0.00001706029,0.0002647254,0.02552489,0.000009044612,0.00004199936,0.0003241761,0.00006213648,0.0004846063,0.9708124,0.00004191477,0.002410416,0.000006659253],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.989648,0.00336845,0.003268895,0.0001018935,0.00004674818,0.00004256422,0.001107848,0.00003497393,0.002380649],"genre_scores_gemma":[0.9830887,0.002164824,0.003484349,0.0001125063,0.00003666991,0.0000775001,0.003807561,0.00002599421,0.00720198],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001016629,"threshold_uncertainty_score":0.002737999,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02707671354956568,"score_gpt":0.2374992944758991,"score_spread":0.2104225809263335,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}