{"id":"W3171411687","doi":"10.1200/jco.2021.39.15_suppl.e16142","title":"Impact of lenvatinib (LEN) dose-intensity and starting dose on survival among patients with advanced hepatocellular carcinoma (HCC): Results from a Canadian multicenter database (HCC CHORD).","year":2021,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Hepatocellular Carcinoma Treatment and Prognosis","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Baker Hughes (Canada); Ottawa Regional Cancer Foundation; Dalhousie University; University Health Network; University of Toronto; Juravinski Cancer Centre; Sunnybrook Health Science Centre; Nova Scotia Cancer Centre; Ottawa Hospital; Princess Margaret Cancer Centre; University of Calgary","funders":"","keywords":"Medicine; Hepatocellular carcinoma; Lenvatinib; Internal medicine; Adverse effect; Liver cancer; Liver disease; Proportional hazards model; Gastroenterology; Portal vein thrombosis; Milan criteria; Response Evaluation Criteria in Solid Tumors; Hazard ratio; Oncology; Progressive disease; Sorafenib; Cirrhosis; Liver transplantation; Disease; Confidence interval; Transplantation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001149083,0.0004133142,0.0006486044,0.001142511,0.0008731597,0.0007287282,0.0008621328,0.000383891,0.00241242],"category_scores_gemma":[0.002467457,0.0002088375,0.001065412,0.003938111,0.0003374075,0.000280555,0.0006144599,0.0005009873,0.0003039797],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0105528,"about_ca_system_score_gemma":0.01257819,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.8119255,"about_ca_topic_score_gemma":0.906498,"domain_scores_codex":[0.9990627,0.00008289583,0.00007921572,0.0002042736,0.0003510771,0.0002198821],"domain_scores_gemma":[0.9975121,0.0002131816,0.0008649248,0.0001592072,0.0007814623,0.0004690958],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002203367,0.00006514256,0.9832389,0.0001956948,0.0005131987,0.00005659484,0.0001303051,0.0002455256,0.0002222781,0.00005915486,0.004346471,0.008723349],"study_design_scores_gemma":[0.0001630296,0.0001395637,0.9965268,0.00006053683,0.0003359565,0.00009611675,0.0001545595,0.000235384,0.00008133017,0.00001735211,0.002173126,0.00001630004],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9471986,0.002658018,0.0001013806,0.0002853548,0.00001379019,0.0001095927,0.04794111,0.0000208843,0.00167129],"genre_scores_gemma":[0.9663942,0.001052658,0.0002492585,0.0001868919,0.00001870148,0.00006069796,0.03150119,0.00001031412,0.0005260987],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1880745,"threshold_uncertainty_score":0.3783643,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1135436390653011,"score_gpt":0.3683170677907923,"score_spread":0.2547734287254912,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}