{"id":"W3171434063","doi":"10.1111/gtc.12879","title":"TAZ inhibits acinar cell differentiation but promotes immature ductal cell proliferation in adult mouse salivary glands","year":2021,"lang":"en","type":"article","venue":"Genes to Cells","topic":"Hippo pathway signaling and YAP/TAZ","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"Japan Society for the Promotion of Science; Tokyo Medical and Dental University; Kyushu University; Japan Agency for Medical Research and Development","keywords":"Ductal cells; Biology; YAP1; Salivary gland; Acinar cell; Progenitor cell; Cell biology; Hippo signaling pathway; Cell growth; Cellular differentiation; Cell; Endocrinology; Stem cell; Internal medicine; Cancer research; Signal transduction; Transcription factor; Pancreas; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002195923,0.0005388768,0.0003409918,0.0005955285,0.0001856174,0.0003246819,0.0002784923,0.0003503619,0.001875972],"category_scores_gemma":[0.0001063473,0.0002269793,0.0004153847,0.0002268534,0.0002910114,0.0002421793,0.0001969325,0.001032233,0.0006049498],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002590328,"about_ca_system_score_gemma":0.0002746345,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006466793,"about_ca_topic_score_gemma":0.001166889,"domain_scores_codex":[0.999788,0.00002794826,0.0000241668,0.00004159338,0.00005653436,0.00006182106],"domain_scores_gemma":[0.9997894,0.00002346712,0.00006408917,0.0000217877,0.00001367396,0.0000874757],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001835488,0.0000632679,0.0001835189,0.00003816359,0.000005402893,0.00003739558,0.00001668442,0.00004162138,0.9981216,0.00008719479,0.00006661057,0.001155014],"study_design_scores_gemma":[0.00005746469,0.0006829944,0.006398324,0.00001362196,0.00002709577,0.0001856963,0.00005975912,0.0008326588,0.987978,0.00007983342,0.003679282,0.000005260174],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9899237,0.003479481,0.002754266,0.0002445373,0.00005659596,0.00004123365,0.001077201,0.0003046383,0.002118378],"genre_scores_gemma":[0.9882884,0.002415342,0.001774843,0.00009557566,0.00001891219,0.00009024575,0.001108034,0.00006451135,0.006144101],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001875972,"threshold_uncertainty_score":0.006275713,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00495118525320782,"score_gpt":0.1989133884602989,"score_spread":0.193962203207091,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}