{"id":"W3171434063","doi":"10.1111/gtc.12879","title":"TAZ inhibits acinar cell differentiation but promotes immature ductal cell proliferation in adult mouse salivary glands","year":2021,"lang":"en","type":"article","venue":"Genes to Cells","topic":"Hippo pathway signaling and YAP/TAZ","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"Japan Society for the Promotion of Science; Tokyo Medical and Dental University; Kyushu University; Japan Agency for Medical Research and Development","keywords":"Ductal cells; Biology; YAP1; Salivary gland; Acinar cell; Progenitor cell; Cell biology; Hippo signaling pathway; Cell growth; Cellular differentiation; Cell; Endocrinology; Stem cell; Internal medicine; Cancer research; Signal transduction; Transcription factor; Pancreas; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001139081,0.0002352103,0.0001888808,0.00007168447,0.00007493203,0.00006058489,0.0001336211,0.0002881941,0.00003216575],"category_scores_gemma":[0.00002604375,0.0002324509,0.00008684951,0.000173515,0.00001535289,0.000008616314,0.000110223,0.0001377552,0.00005970334],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002106156,"about_ca_system_score_gemma":0.0001256433,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000250261,"about_ca_topic_score_gemma":0.0000978568,"domain_scores_codex":[0.9985467,0.0001234385,0.0002877438,0.0005382534,0.0001820227,0.000321805],"domain_scores_gemma":[0.9992539,0.000008200908,0.00008335891,0.0003426108,0.0001916532,0.0001202612],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000100552,0.0002229865,0.001102539,0.0001037477,0.00001021977,0.00002164185,0.0003790596,0.0004225371,0.9968618,0.000001951901,0.0002817302,0.0004912717],"study_design_scores_gemma":[0.000668243,0.0002449559,0.0004122665,0.00002462533,0.00001559508,0.00001104442,0.0001328919,0.0001588335,0.9970691,0.00001021916,0.0009623455,0.0002898596],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972718,0.0009174376,0.0006846369,0.0001266401,0.0002223597,0.0003245388,0.00009869445,0.00002505744,0.0003288487],"genre_scores_gemma":[0.9914923,0.000228878,0.001105627,0.0002601143,0.0003898134,0.00004361287,0.001147986,0.00003948623,0.005292159],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005779462,"threshold_uncertainty_score":0.9479071,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00495118525320782,"score_gpt":0.1989133884602989,"score_spread":0.193962203207091,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}