{"id":"W3171489626","doi":"10.1038/s41385-021-00411-9","title":"Cigarette smoke exposure attenuates the induction of antigen-specific IgA in the murine upper respiratory tract","year":2021,"lang":"en","type":"article","venue":"Mucosal Immunology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":14,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University Medical Centre; St. Joseph’s Healthcare Hamilton; Weston Family Foundation; Western University; McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Lung Health Foundation","keywords":"Immunology; Respiratory tract; Immunoglobulin A; Ovalbumin; Antigen; Immune system; Immunity; Mucous membrane of nose; Medicine; Lipopolysaccharide; Respiratory system; Biology; Immunoglobulin G; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0005922198,0.0002049188,0.0003137327,0.0001631529,0.0002404109,0.0000224209,0.0003650951,0.0003827545,0.001811015],"category_scores_gemma":[0.0001294321,0.0001332832,0.0001609702,0.0003899631,0.0004051831,0.0001604444,0.00009251892,0.001044392,0.0002345316],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005045056,"about_ca_system_score_gemma":0.00007288234,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001098828,"about_ca_topic_score_gemma":0.0000347714,"domain_scores_codex":[0.9976305,0.001074022,0.0005593111,0.0003235006,0.00006060954,0.0003520911],"domain_scores_gemma":[0.9986197,0.0003056749,0.0002219025,0.0006698245,0.0001763693,0.00000655383],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0003545503,0.0003672705,0.01895989,0.000006936538,0.0002126945,0.00001938398,0.001398176,0.000004848102,0.9582277,0.001863281,0.009082972,0.009502316],"study_design_scores_gemma":[0.001000124,0.0002717972,0.4080049,0.00002037397,0.00001578321,0.0002939071,0.003221749,4.52299e-7,0.2767903,0.00009564617,0.3101645,0.0001203485],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9647362,0.02552951,0.00002352175,0.00314561,0.004999671,0.000203316,0.000004849489,0.00003732775,0.00132003],"genre_scores_gemma":[0.9963902,0.001209313,0.000005792946,0.001085995,0.00008270491,0.00003938807,0.000123269,0.00001942386,0.001043938],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6814374,"threshold_uncertainty_score":0.9991015,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02977666340747115,"score_gpt":0.2496508244038208,"score_spread":0.2198741609963496,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}