{"id":"W3171509414","doi":"10.1200/jco.2021.39.15_suppl.9501","title":"Final analysis of overall survival (OS) and relapse-free-survival (RFS) in the intergroup S1404 phase III randomized trial comparing either high-dose interferon (HDI) or ipilimumab to pembrolizumab in patients with high-risk resected melanoma.","year":2021,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; Sunnybrook Health Science Centre","funders":"National Institutes of Health","keywords":"Medicine; Ipilimumab; Pembrolizumab; Internal medicine; Melanoma; Adjuvant; Randomized controlled trial; Surgery; Lymph node; Oncology; Gastroenterology; Immunotherapy; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.007784656,0.001417276,0.002236166,0.0004699225,0.000297295,0.0009806873,0.001225759,0.001216857,0.006278173],"category_scores_gemma":[0.003416841,0.0004757595,0.003964045,0.0003868494,0.0009030633,0.0008121371,0.0005655578,0.002724024,0.0005092096],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001049479,"about_ca_system_score_gemma":0.001517388,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006381266,"about_ca_topic_score_gemma":0.001706277,"domain_scores_codex":[0.9969842,0.002377154,0.0001138282,0.0002240236,0.0001082664,0.0001924536],"domain_scores_gemma":[0.9975955,0.0009107674,0.0004904557,0.0002106826,0.0001230162,0.0006696935],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9867995,0.001375625,0.001717568,0.0001887922,0.001245922,0.00001606653,0.00001779341,0.0006550712,0.001221641,0.00008377134,0.0005271311,0.006151204],"study_design_scores_gemma":[0.825166,0.1523405,0.01466417,0.00005312288,0.003188572,0.00004980444,0.00002589674,0.001852531,0.001089332,0.0003602795,0.001188191,0.00002152652],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9838054,0.003523972,0.001778977,0.0007964917,0.0002923972,0.003835308,0.002918408,0.0000895056,0.002959643],"genre_scores_gemma":[0.9882116,0.0006308688,0.002144697,0.000484969,0.0002015632,0.003185601,0.003013236,0.00002368231,0.002103732],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007784656,"threshold_uncertainty_score":0.04116964,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07201326935886022,"score_gpt":0.4037477433336764,"score_spread":0.3317344739748161,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}