{"id":"W3171523991","doi":"10.1021/acs.jmedchem.1c00539","title":"Development of [<sup>18</sup>F]AldoView as the First Highly Selective Aldosterone Synthase PET Tracer for Imaging of Primary Hyperaldosteronism","year":2021,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Hormonal Regulation and Hypertension","field":"Medicine","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"FP7 Health; Barts and The London School of Medicine and Dentistry; UCLH Biomedical Research Centre; Medical Research Council; Barts Charity; Efficacy and Mechanism Evaluation Programme; National Institute for Health and Care Research; Mallinckrodt Pharmaceuticals; University College London; Wellcome Trust","keywords":"Hyperaldosteronism; Chemistry; Aldosterone; Aldosterone synthase; TRACER; Positron emission tomography; Adrenal cortex; Radiochemistry; Endocrinology; Nuclear medicine; Biochemistry; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001102839,0.0006195552,0.0005742783,0.0004506759,0.0003138001,0.0009947446,0.0009523161,0.001289121,0.001594731],"category_scores_gemma":[0.0007391259,0.0004983689,0.0004656758,0.0002781471,0.0005708024,0.001318682,0.000440297,0.001195508,0.0007060869],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004069395,"about_ca_system_score_gemma":0.00108092,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009849548,"about_ca_topic_score_gemma":0.001328211,"domain_scores_codex":[0.999792,0.00007881537,0.000009037703,0.0000467101,0.00003078764,0.00004268785],"domain_scores_gemma":[0.9998097,0.00004911297,0.00002266185,0.00002567011,0.0000431137,0.00004974719],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001743548,0.0002392305,0.001550705,0.000415556,0.0001351567,0.001689352,0.0001247434,0.0007365738,0.9036983,0.003476938,0.001645669,0.0845442],"study_design_scores_gemma":[0.0006141826,0.004212467,0.003148685,0.0001343528,0.0003177534,0.01058023,0.0001026482,0.00561255,0.9145916,0.001458057,0.05913645,0.00009107088],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6400483,0.09895284,0.2280741,0.005733639,0.00129107,0.001144341,0.0009567394,0.001397603,0.02240134],"genre_scores_gemma":[0.8547122,0.01896658,0.1146594,0.001508632,0.0003115715,0.0004502652,0.001307178,0.0002334745,0.007850668],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001594731,"threshold_uncertainty_score":0.005832434,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02433793120324792,"score_gpt":0.275789604199733,"score_spread":0.2514516729964851,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}